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Evaluation of a flow-photochemistry platform for the synthesis of functionalized benzobicyclo[3.2.1]-skeleton (CROSBI ID 658842)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Ratković, Ana ; Kelava, Vanja ; Marinić, Željko ; Škorić, Irena Evaluation of a flow-photochemistry platform for the synthesis of functionalized benzobicyclo[3.2.1]-skeleton // Central European Conference on Photochemistry (CECP 2018) : Book of Abstracts. Bad Hofgastein, 2018. str. 62-62

Podaci o odgovornosti

Ratković, Ana ; Kelava, Vanja ; Marinić, Željko ; Škorić, Irena

engleski

Evaluation of a flow-photochemistry platform for the synthesis of functionalized benzobicyclo[3.2.1]-skeleton

Bicyclo[3.2.l]-skeleton is a common subunit in many natural products such as diterpenes and sesquiterpenes [1a]. Compounds that have this core as a base have been tested and are proved as potent inhibitors of dopamine and serotonin transporters and also play crucial role in treatment of CNS and Alzheimer’s disorders [1b, c]. On the other hand, photochemical synthesis gave a pathway to a whole library of polycyclic compounds that include a vast number of structures with the benzobicyclo[3.2.1]octadiene moiety [2]. To apply an even more powerful tool for this targeted functionalized substrate, continuous flow photochemical system was used for the first time [3] enabling us to scale-up the intramolecular cycloaddition reaction without scaling-up the equipment. For all of the obtained novel potentially bioactive derivatives preliminary physico-chemical properties were also analyzed

Benzobicyclo[3.2.1]octadienes ; Continuos flow system ; Flow-photochemistry ; Intramolecular photocycloaddition ; Physico-chemical and ADME properties

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Podaci o prilogu

62-62.

2018.

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objavljeno

Podaci o matičnoj publikaciji

Central European Conference on Photochemistry (CECP 2018) : Book of Abstracts

Bad Hofgastein:

Podaci o skupu

Central European Conference on Photochemistry (CECP 2018)

poster

04.02.2018-08.02.2018

Bad Hofgastein, Austrija

Povezanost rada

Kemija