engleski

Assessment of microbiota, inflammatory markers, nutritional and endocrinological status in IBD patients - Minute for IBD

Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder increasing in incidence and severely influencing affected individuals. Although the factors associated with the disease risk include immune status, gut microbiome and several environmental causes including food intake, the current scientific knowledge of specific triggers and diagnostic markers to improve interventional approaches is still scarce. Additional basic and clinical research involving specific groups of patients and obtaining multilevel data are essential for the management of the disease. Investigation of mutual correlation between gut microbiota, inflammatory, endocrine and nutritional status provides integrative framework for better understanding the IBD pathophysiology. MINUTE for IBD project’s scope is to perform the best possible systematic analysis of relevant elements and factors (gut microbiota composition, inflammatory/endocrine markers, nutritional status) contributing to the development and progress of IBD on newly diagnosed, therapy naïve IBD patients and individuals not fulfilling IBD diagnosis criteria as a control. Through an integrated translational approach, two skilled groups of experts (academic and clinical) are focused on accomplishing the main scope of the project. Analysis of microbiota composition (by 16S rRNA gene sequencing) in stools and in mucosa, quantification of relevant immune and endocrine biomarkers in blood samples, determination of overall nutritional status in study participants and integration of the obtained results and setting-up better guiding principles when deciding on the therapy and nutritional intervention in IBD patients

Inflammatory bowel disease, gut microbiome, inflammatory, endocrine and nutritional status

nije evidentirano