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Pregled bibliografske jedinice broj: 925011

Photophysical properties and photochemical reactivity of tripeptides containing quinone methide precursors


Husak, Antonija; Basarić, Nikola
Photophysical properties and photochemical reactivity of tripeptides containing quinone methide precursors // Central European Conference on Photochemistry (CECP 2018) : Book of Abstracts
Bad Hofgastein, 2018. str. P30-P30 (poster, međunarodna recenzija, sažetak, znanstveni)


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Naslov
Photophysical properties and photochemical reactivity of tripeptides containing quinone methide precursors

Autori
Husak, Antonija ; Basarić, Nikola

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Central European Conference on Photochemistry (CECP 2018) : Book of Abstracts / - Bad Hofgastein, 2018, P30-P30

Skup
Central European Conference on Photochemistry (CECP 2018)

Mjesto i datum
Bad Hofgastein, Austrija, 04-08.02.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
peptides ; tryptophan ; quinone methides ; photodeamination ; DNA binding

Sažetak
Quinone methides (QMs) are reactive intermediates in the chemistry and photochemistry of phenols involved in a large number of chemical and biological processes such as enzyme inhibition, DNA alkylation and cross-linking [1]. Furthermore, it has been demonstrated that QMs exhibit antiproliferative activity, showing potential to be developed into anticancer drugs [2]. One strategy to enhance QMs reactivity with DNA and their antiproliferative activity is to bind the QM precursors to DNA intercallators [3]. We have recently demonstrated that modified tyrosine incorporated in oligopeptides can deliver QMs in the photochemical deamination reaction [3]. Herein we present photophysical properties and photochemical reactivity of tripeptide 1 that contains QM precursor - modified tyrosine and the TrpTrp dipeptide. The TrpTrpTyr sequence was chosen due to its known DNA binding ability [4], as well as fluorescent properties of Trp. Non- covalent and covalent binding of tripeptide 1 to DNA was assayed by fluorescence and CD titrations and by irradiations in the presence of DNA, respectively.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
IP-2014-09-6312 - Supramolekulska kontrola fotokemijskih reakcija eliminacije (SupraPhotoE) (Basarić, Nikola, HRZZ - 2014-09) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Antonija Erben (autor)

Avatar Url Nikola Basarić (autor)


Citiraj ovu publikaciju:

Husak, Antonija; Basarić, Nikola
Photophysical properties and photochemical reactivity of tripeptides containing quinone methide precursors // Central European Conference on Photochemistry (CECP 2018) : Book of Abstracts
Bad Hofgastein, 2018. str. P30-P30 (poster, međunarodna recenzija, sažetak, znanstveni)
Husak, A. & Basarić, N. (2018) Photophysical properties and photochemical reactivity of tripeptides containing quinone methide precursors. U: Central European Conference on Photochemistry (CECP 2018) : Book of Abstracts.
@article{article, author = {Husak, Antonija and Basari\'{c}, Nikola}, year = {2018}, pages = {P30-P30}, keywords = {peptides, tryptophan, quinone methides, photodeamination, DNA binding}, title = {Photophysical properties and photochemical reactivity of tripeptides containing quinone methide precursors}, keyword = {peptides, tryptophan, quinone methides, photodeamination, DNA binding}, publisherplace = {Bad Hofgastein, Austrija} }
@article{article, author = {Husak, Antonija and Basari\'{c}, Nikola}, year = {2018}, pages = {P30-P30}, keywords = {peptides, tryptophan, quinone methides, photodeamination, DNA binding}, title = {Photophysical properties and photochemical reactivity of tripeptides containing quinone methide precursors}, keyword = {peptides, tryptophan, quinone methides, photodeamination, DNA binding}, publisherplace = {Bad Hofgastein, Austrija} }




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