engleski

Assessing the human lithium environmental exposure

The aim of this study was to assess the human environmental Li exposure by studying Li frequency distribution in the hair (H•Li) and whole blood (WB•Li). Hair (H) was collected in 1073 healthy adult subjects (339 male and 734 female) ; blood Li (B•Li) was analyzed in the sub-population of 91 male and 143 female). Samples were analyzed for Li with the ICP-MS at the CBM, Moscow, Russia. The frequency distribution of H•Li and B•Li WB•Li was analyzed with the median derivative bioassay method. The H•Li bioassay sigmoid curve was linear (adequate) for the range of (µg/g) 0.014-0.086 and 0.016- 0.100 in male and female, respectively. The WB•Li medians were 3.45-5.48 for male and 3.24-5.64 in male and female respectively. The below 0.014 for female and 0.015 µg/g for male are Li deficient, and those above 0.086 in female and 0.100 in male as Li excessive: B•Li conc’s below 3.45 and 3.24 are regarded as Li deficient and those above 5.48 and 5.63 as Li excessive in male and female, respectively. Conclusions: (B•Li) > (H•Li) is good long term biological indicator for assessing the Li exposure.

lithium, human, environmental, assessing, exposure

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