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The Early Dendritic Cell Signaling Induced by Virulent Francisella tularensis Strain Occurs in Phases and Involves the Activation of Extracellular Signal-Regulated Kinases (ERKs) and p38 In the Later Stage (CROSBI ID 248090)

Prilog u časopisu | izvorni znanstveni rad

Fabrik, I. ; Link, M. ; Putzova, D. ; Plzakova, L. ; Lubovska, Z. ; Philimonenko, V. ; Pavkova, I. ; Rehulka, P. ; Krocova, Z. ; Hozak, P. et al. The Early Dendritic Cell Signaling Induced by Virulent Francisella tularensis Strain Occurs in Phases and Involves the Activation of Extracellular Signal-Regulated Kinases (ERKs) and p38 In the Later Stage // Molecular & cellular proteomics, 17 (2018), 1; 81-94. doi: 10.1074/mcp.RA117.000160

Podaci o odgovornosti

Fabrik, I. ; Link, M. ; Putzova, D. ; Plzakova, L. ; Lubovska, Z. ; Philimonenko, V. ; Pavkova, I. ; Rehulka, P. ; Krocova, Z. ; Hozak, P. ; Šantić, Marina ; Stulík, J.

engleski

The Early Dendritic Cell Signaling Induced by Virulent Francisella tularensis Strain Occurs in Phases and Involves the Activation of Extracellular Signal-Regulated Kinases (ERKs) and p38 In the Later Stage

Dendritic cells (DCs) infected by Francisella tularensis are poorly activated and do not undergo classical maturation process. Although reasons of such unresponsiveness are not fully understood, their impact on the priming of immunity is well appreciated. Previous attempts to explain the behavior of Francisella-infected DCs were hypothesisdriven and focused on events at later stages of infection. Here, we took an alternative unbiased approach by applying methods of global phosphoproteomics to analyze the dynamics of cell signaling in primary DCs during the first hour of infection by Francisella tularensis. Presented results show that the early response of DCs to Francisella occurs in phases and that ERK and p38 signaling modules induced at the later stage are differentially regulated by virulent and attenuated dsbA strain. These findings imply that the temporal orchestration of host proinflammatory pathways represents the integral part of Francisella life-cycle inside hijacked DCs.

Francisella, dendritic cells, ERK

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Podaci o izdanju

17 (1)

2018.

81-94

objavljeno

1535-9476

1535-9484

10.1074/mcp.RA117.000160

Povezanost rada

nije evidentirano

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