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Pregled bibliografske jedinice broj: 923118

Autophagy modulation in cancer: Current knowledge on action and therapy


Marinković, Mija; Šprung, Matilda; Buljubašić, Maja; Novak, Ivana
Autophagy modulation in cancer: Current knowledge on action and therapy // Oxidative medicine and cellular longevity, 2018 (2018), 8023821, 18 doi:10.1155/2018/8023821 (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
Autophagy modulation in cancer: Current knowledge on action and therapy

Autori
Marinković, Mija ; Šprung, Matilda ; Buljubašić, Maja ; Novak, Ivana

Izvornik
Oxidative medicine and cellular longevity (1942-0900) 2018 (2018); 8023821, 18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Autophagy, autophagy modulators, cancer, cancer therapy, and clinical trials

Sažetak
In the last two decades, accumulating evidence pointed to the importance of autophagy in various human diseases. As an essential evolutionary catabolic process of cytoplasmatic component digestion, it is generally believed that modulating autophagic activity, through targeting specific regulatory actors in the core autophagy machinery, may impact disease processes. Both autophagy upregulation and downregulation have been found in cancers, suggesting its dual oncogenic and tumor suppressor properties during malignant transformation. Identification of the key autophagy targets is essential for the development of new therapeutic agents. Despite this great potential, no therapies are currently available that specifically focus on autophagy modulation. Although drugs like rapamycin, chloroquine, hydroxychloroquine, and others act as autophagy modulators, they were not originally developed for this purpose. Thus, autophagy may represent a new and promising pharmacologic target for future drug development and therapeutic applications in human diseases. Here, we summarize our current knowledge in regard to the interplay between autophagy and malignancy in the most significant tumor types: pancreatic, breast, hepatocellular, colorectal, and lung cancer, which have been studied in respect to autophagy manipulation as a promising therapeutic strategy. Finally, we present an overview of the most recent advances in therapeutic strategies involving autophagy modulators in cancer.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

Napomena
CNKI Scholar ; DOAJ ; EBSCOhost ; Engineering Village ; Google Scholar ; HINARI Access to Research in Health Programme ; J-Gate ; Portal Journal Citation Reports-Science Edition ; GoOA ; J-Gate ; Primo Central Index ; The Summon Service



POVEZANOST RADA


Projekt / tema
HRZZ-UIP-2013-11-5246 - Uloga receptora autofagije u selektivnom uklanjanju mitohondrija (Ivana Nakir, )

Ustanove
Prirodoslovno-matematički fakultet, Split,
Medicinski fakultet, Split

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • CA Search (Chemical Abstracts)
  • Compendex (EI Village)
  • EMBASE (Excerpta Medica)
  • CNKI Scholar
  • DOAJ
  • EBSCOhost
  • Engineering Village
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • J-Gate
  • Portal Journal Citation Reports-Science Edition
  • GoOA
  • J-Gate
  • Primo Central Index
  • The Summon Service


Citati