engleski

Automated determination of active compounds in pharmaceutical formulations by flow injection analysis

Flow injection analysis (FIA) is an automated technique with numerous applications in quantitative chemical analysis. From the beginning in 1975 when Hansen and Ružička introduced FIA for the first time, till today, more then 17000 scientific papers and 20 monographs have been published. FIA is a kinetic method of analysis ; signal is recorded in the moment when the chemical reaction did not proceed to thermodynamic equilibrium. In contrast to the conventional continuous flow procedures and batch methods, FIA do not rely on complete mixing of sample and reagent(s) (physical homogenization). In recent years, more strict regulation related to the quality control in pharmaceuticals led to increasing demands on automation of the analytical assays carried out in appropriate control laboratories. FIA became a versatile instrumental tool that contributed substantially to the development of automation in pharmaceutical analysis due to its simplicity, low cost and relatively short analysis time. In this work the developed flow injection methods with spectrophotometric detector for the determination of thiol compounds (active substances in pharmaceutical formulations) will be presented. The selectivity of the developed methods based on the reaction mechanism will be discussed. 1 J. Ružička ; E. H. Hansen, Analytica Chimica Acta, 78 (1975) 145-157.

flow injection analysis, thiol compounds, pharmaceutical formulations

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