engleski

Azithromycin versus Amoxicillin/Clavunalate in treatment of odontogenic infections

An open comparative study was undertaken to compare the efficacy and safety of Azithromycin and Amoxicillin/Clavulante in the treatment of odontogenic infection. Adult pacients of both sexes with acute or exacerbating apical parodontitis, who gave their informed consent, were randomized to recive Azithromycin (Sumamed, Pliva, Croatia), 500 mg once only daily for 3 days, or Amoxicillin/Clavulante (klavocin, Pliva), 625 mg every 8 h for 5 days. Clinical evaluation (dental pain swelling, exudation, regional lymphadenopathy, trismus, fever) was performed before and 3, 5 and 10 days after initiation of treatment. Cure was defined as complete dissapearance of signs and symptoms of acute infection within 5 days of initiating treatment. Thirty-eight patients, aged 21-77 years, have been included (17 Azithromycin, and 21 in Amoxicillin/Clavulante group). Treatment groups were comparable with respect to demographic and case history data. Cure was achieved in 15/16 Azithromycin treated patients (one patient excluded from evaulation due to treatment discontinuation caused by diarrhoea), and in all patients reciving Amoxicillin Clavulante. Besides the patient with diarrhoea, mild side effects (nausea and vaginitis) were observed in two patient receiving Azthromycin. These Azithromycin course may be as effective as 5-day Amoxicilln/Clavulante course.

azithromycin; amoxicillin/clavulante; odontogenic infection

nije evidentirano