Novel NALCN variant: altered respiratory and circadian rhythm, anesthetic sensitivity (CROSBI ID 247693)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Lozić, Bernarda ; Johansson, Stefan ; Lovrić Kojundžić, Sanja ; Markić, Joško ; Knappskog, Per Morten ; Hahn, Angelika F. ; Boman, Helge
engleski
Novel NALCN variant: altered respiratory and circadian rhythm, anesthetic sensitivity
The sodium leak channel, a Na+-permeable, nonselective cation channel, is widely expressed in the nervous system, contributing a basal Na+- leak conductance and regulating neuronal excitability. A 3-year-old girl, heterozygous for a de novo missense mutation in NALCN (c.956C>T ; p.Ala319Val) predicted to be deleterious, presented from birth with: stimulus-induced, episodic contractures of the limbs and face with associated respiratory distress ; distal arthrogryposis ; severe axial hypotonia ; and severe global developmental delay (CLIFAHDD syndrome). In infancy, she manifested a reversed sleep-wake rhythm, nocturnal life-threatening respiratory rhythm disturbances with central apnea. Sevoflurane sensitivity caused respiratory depression and cardiac arrest.
NALCN ; sodium leak channel ; infancy
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Podaci o izdanju
3 (11)
2016.
876-883
objavljeno
2328-9503
10.1002/acn3.362
Povezanost rada
Kliničke medicinske znanosti, Temeljne medicinske znanosti