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Pregled bibliografske jedinice broj: 921479

Circumventing Antivector Immunity: Potential Use of Nonhuman Adenoviral Vectors


Lopez-Gordo, Estrella; Podgorski, Iva; Downes, Nicholas; Alemany, Ramon
Circumventing Antivector Immunity: Potential Use of Nonhuman Adenoviral Vectors // Human gene therapy, 25 (2014), 4; 285-300 doi:10.1089/hum.2013.228 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
Circumventing Antivector Immunity: Potential Use of Nonhuman Adenoviral Vectors

Autori
Lopez-Gordo, Estrella ; Podgorski, Iva ; Downes, Nicholas ; Alemany, Ramon

Izvornik
Human gene therapy (1043-0342) 25 (2014), 4; 285-300

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
adenovirus ; gene therapy ; non-human adenovirus ; delivery vector

Sažetak
Adenoviruses are efficient gene delivery vectors based on their ability to transduce a wide variety of cell types and drive high-level transient transgene expression. While there have been advances in modifying human adenoviral (HAdV) vectors to increase their safety profile, there are still pitfalls that need to be further addressed. Preexisting humoral and cellular immunity against common HAdV serotypes limits the efficacy of gene transfer and duration of transgene expression. As an alternative, nonhuman AdV (NHAdV) vectors can circumvent neutralizing antibodies against HAdVs in immunized mice and monkeys and in human sera, suggesting that NHAdV vectors could circumvent preexisting humoral immunity against HAdVs in a clinical setting. Consequently, there has been an increased interest in developing NHAdV vectors for gene delivery in humans. In this review, we outline the recent advances and limitations of HAdV vectors for gene therapy and describe examples of NHAdV vectors focusing on their immunogenicity, tropism, and potential as effective gene therapy vehicles.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Profili:

Avatar Url Iva Škrinjar (autor)

Citiraj ovu publikaciju:

Lopez-Gordo, Estrella; Podgorski, Iva; Downes, Nicholas; Alemany, Ramon
Circumventing Antivector Immunity: Potential Use of Nonhuman Adenoviral Vectors // Human gene therapy, 25 (2014), 4; 285-300 doi:10.1089/hum.2013.228 (međunarodna recenzija, pregledni rad, znanstveni)
Lopez-Gordo, E., Podgorski, I., Downes, N. & Alemany, R. (2014) Circumventing Antivector Immunity: Potential Use of Nonhuman Adenoviral Vectors. Human gene therapy, 25 (4), 285-300 doi:10.1089/hum.2013.228.
@article{article, author = {Lopez-Gordo, Estrella and Podgorski, Iva and Downes, Nicholas and Alemany, Ramon}, year = {2014}, pages = {285-300}, DOI = {10.1089/hum.2013.228}, keywords = {adenovirus, gene therapy, non-human adenovirus, delivery vector}, journal = {Human gene therapy}, doi = {10.1089/hum.2013.228}, volume = {25}, number = {4}, issn = {1043-0342}, title = {Circumventing Antivector Immunity: Potential Use of Nonhuman Adenoviral Vectors}, keyword = {adenovirus, gene therapy, non-human adenovirus, delivery vector} }
@article{article, author = {Lopez-Gordo, Estrella and Podgorski, Iva and Downes, Nicholas and Alemany, Ramon}, year = {2014}, pages = {285-300}, DOI = {10.1089/hum.2013.228}, keywords = {adenovirus, gene therapy, non-human adenovirus, delivery vector}, journal = {Human gene therapy}, doi = {10.1089/hum.2013.228}, volume = {25}, number = {4}, issn = {1043-0342}, title = {Circumventing Antivector Immunity: Potential Use of Nonhuman Adenoviral Vectors}, keyword = {adenovirus, gene therapy, non-human adenovirus, delivery vector} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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