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Biological testings of mechanochemicaly obtained aroyl hydrazones as perspective ligands for metal complexes (CROSBI ID 657886)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Pisk, Jana ; Rubčić, Mirta ; Cvijanović, Danijela ; Damjanović, Vladimir ; Lovrić, Jasna ; Cindrić, Marina ; Vrdoljak, Višnja Biological testings of mechanochemicaly obtained aroyl hydrazones as perspective ligands for metal complexes // 14 th International Symposium on Applied Bioinorganic Chemistry : Conference Book. 2017. str. 167-167

Podaci o odgovornosti

Pisk, Jana ; Rubčić, Mirta ; Cvijanović, Danijela ; Damjanović, Vladimir ; Lovrić, Jasna ; Cindrić, Marina ; Vrdoljak, Višnja

engleski

Biological testings of mechanochemicaly obtained aroyl hydrazones as perspective ligands for metal complexes

In recent years, mechanochemistry is attracting interest and sympathy of many scientist [1]. In general, it is promoted by hand grinding or ball milling [2]. Ball milling is an efficient method, commonly used both in organic and inorganic chemistry. Hydrazones are class of as chelating agents, used in coordination chemistry and their metal complexes are of a great importance. The significance of studying hydrazones arises from the fact that they have increased biological activity and they form particular materials with unique properties [3, 4]. In particular are known as antioxidants, vasidilatators, agents again tuberculosis and tumors, ect. [5, 6] Moreover, molybdenum complexes with hydrazone ligands have been reported to possess interesting antibacterial activities. The presented research considers green protocol and highly efficient synthesis of series of aromatic hydrazones. [7]. Ball milling was deliberated as solventless method promoting eco-friendly reaction conditions. The ligands were prepared by the condensation of salicylaldehyde derivative (A1-3) and appropriate hydrazide (isoniaside or nicotinic acid hydrazide, H1-3), as shown in the Scheme 1. Solid state preparative procedures were also followed by conventional synthetic procedure, in solution, and different forms of ligands were isolated (polymorphs and solvates), whose molecular and crystal structure was determined by the single crystal diffraction method. Molybdenum(VI) mononuclear and dinuclear complex with the obtained ligands were synthesized and characterized. The prepared compounds were biologically tested. With the targeted synthetic policy and recognized correlation of structure and activity, biologically active compounds can be evolved and expanded.

aroyl hydrazones, mechanochemistry, ball milling

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Podaci o prilogu

167-167.

2017.

objavljeno

Podaci o matičnoj publikaciji

14 th International Symposium on Applied Bioinorganic Chemistry : Conference Book

Podaci o skupu

14 th International Symposium on Applied Bioinorganic Chemistry

poster

07.06.2017-10.06.2017

Toulouse, Francuska

Povezanost rada

Kemija