Napredna pretraga

Pregled bibliografske jedinice broj: 920873

Voltammetric Characterisation of Anticancer Drug Irinotecan


Novak Jovanović, Ivana; Komorsky-Lovrić, Šebojka; Lucić Vrdoljak, Ana; Popović, Aleksandar; Neuberg, Marijana
Voltammetric Characterisation of Anticancer Drug Irinotecan // Electroanalysis, 30 (2018), 2; 336-344 doi:10.1002/elan.201700593 (međunarodna recenzija, članak, znanstveni)


Naslov
Voltammetric Characterisation of Anticancer Drug Irinotecan

Autori
Novak Jovanović, Ivana ; Komorsky-Lovrić, Šebojka ; Lucić Vrdoljak, Ana ; Popović, Aleksandar ; Neuberg, Marijana

Izvornik
Electroanalysis (1040-0397) 30 (2018), 2; 336-344

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Adsorptive stripping square-wave voltammetry ; electroanalytical determination ; irinotecan ; redox mechanism ; square-wave voltammetry

Sažetak
Electrochemical reduction of irinotecan was investigated on a static mercury drop electrode using square-wave voltammetry. The mechanism of irinotecan electroreduction is a complex, pH- dependent, quasireversible process and includes the transfer of two electrons and two protons. In acidic medium, the first electron transfer reaction is followed by the chemical reaction, and the product of this chemical reaction undergoes further electrochemical reduction at more negative potentials. Both irinotecan and the product of its reduction adsorb on the mercury electrode surface. Based on the adsorptive character of irinotecan, a new adsorptive stripping square-wave voltammetric method for its electroanalytical determination has been proposed. The voltammetric response could be used to determine irinotecan in the concentration range from 1×10−7 mol/L to 1.5×10−6 mol/L and from 5×10−9 mol/L to 1.2×10−7 mol/L, if the accumulation time is 20 s and 300 s, respectively. The calculated limit of detection for irinotecan was found to be 8.7×10−9 mol/L (if tacc=300 s).

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Prehrambena tehnologija



POVEZANOST RADA


Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Sveučilište Sjever, Koprivnica

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • CA Search (Chemical Abstracts)
  • CCR Database
  • Chemical Abstracts Service
  • Chemistry Server Reaction Center
  • Chimica Database
  • Journal Citation Reports/Science Edition
  • Reaction Citation Index
  • VINITI


Citati