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Malignant spindle cell tumor - Carcinoma or sarcoma?

Spindle cell carcinoma (SpCC) is a rare subvariant of upper aerodigestive tract mucosal squamous cell carcinoma. The histological appearance of SpCC is characterized by dual composition of malignant squamous carcinoma cells and malignant sarcoma-like spindle cells. The spindle cells are not specific for SpCC, but are present in various other malignant, benign and inflammatory lesions. Subsequently, accurate pathological diagnosis of SpCC is challenging. Although there are no clear treatment guidelines, it is widely regarded that SpCC should be treated as SCC of the corresponding localization and disease stage.

spindle cell carcinoma, carcinosarcoma, collision tumor, head and neck squamos cell carcinoma

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