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Pregled bibliografske jedinice broj: 919723

Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis


Lavtar, Polona; Rudolf, Goražd; Maver, Aleš; Hodžić, Alenka; Starčević Čizmarević, Nada; Živković, Maja; Šega Jazbec, Saša; Klemenc Ketiš, Zalika; Kapović, Miljenko; Dinčić, Evica et al.
Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis // PLoS One, 13 (2018), 1; e0190601, 7 doi:10.1371/journal.pone.0190601 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 919723 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis

Autori
Lavtar, Polona ; Rudolf, Goražd ; Maver, Aleš ; Hodžić, Alenka ; Starčević Čizmarević, Nada ; Živković, Maja ; Šega Jazbec, Saša ; Klemenc Ketiš, Zalika ; Kapović, Miljenko ; Dinčić, Evica ; Raičević, Ranko ; Sepčić, Juraj ; Lovrečić, Luca ; Stanković, Aleksandra ; Ristić, Smiljana ; Peterlin, Borut.

Izvornik
PLoS One (1932-6203) 13 (2018), 1; E0190601, 7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Multiple Sclerosis ; Circadian rhythm genes

Sažetak
Prevalence of multiple sclerosis varies with geographic latitude. We hypothesized that this fact might be partially associated with the influence of latitude on circadian rhythm and consequently that genetic variability of key circadian rhythm regulators, ARNTL and CLOCK genes, might contribute to the risk for multiple sclerosis. Our aim was to analyse selected polymorphisms of ARNTL and CLOCK, and their association with multiple sclerosis. A total of 900 Caucasian patients and 1024 healthy controls were compared for genetic signature at 8 SNPs, 4 for each of both genes. We found a statistically significant difference in genotype (ARNTL rs3789327, P = 7.510−5 ; CLOCK rs6811520 P = 0.02) distributions in patients and controls. The ARNTL rs3789327 CC genotype was associated with higher risk for multiple sclerosis at an OR of 1.67 (95% CI 1.35–2.07, P = 0.0001) and the CLOCK rs6811520 genotype CC at an OR of 1.40 (95% CI 1.13–1.73, P = 0.002). The results of this study suggest that genetic variability in the ARNTL and CLOCK genes might be associated with risk for multiple sclerosis.

Izvorni jezik
Engleski



POVEZANOST RADA


Ustanove
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Lavtar, Polona; Rudolf, Goražd; Maver, Aleš; Hodžić, Alenka; Starčević Čizmarević, Nada; Živković, Maja; Šega Jazbec, Saša; Klemenc Ketiš, Zalika; Kapović, Miljenko; Dinčić, Evica et al.
Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis // PLoS One, 13 (2018), 1; e0190601, 7 doi:10.1371/journal.pone.0190601 (međunarodna recenzija, članak, znanstveni)
Lavtar, P., Rudolf, G., Maver, A., Hodžić, A., Starčević Čizmarević, N., Živković, M., Šega Jazbec, S., Klemenc Ketiš, Z., Kapović, M. & Dinčić, E. (2018) Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis. PLoS One, 13 (1), e0190601, 7 doi:10.1371/journal.pone.0190601.
@article{article, year = {2018}, pages = {7}, DOI = {10.1371/journal.pone.0190601}, chapter = {e0190601}, keywords = {Multiple Sclerosis, Circadian rhythm genes}, journal = {PLoS One}, doi = {10.1371/journal.pone.0190601}, volume = {13}, number = {1}, issn = {1932-6203}, title = {Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis}, keyword = {Multiple Sclerosis, Circadian rhythm genes}, chapternumber = {e0190601} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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