Synthesis and antiproliferative activity of novel 2-substituted N-methylated benzimidazoles and tetracyclic benzimidazo[1,2-a]quinolines (CROSBI ID 246873)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Perin, Nataša ; Škulj, Sanja ; Martin-Kleiner, Irena ; Kralj, Marijeta ; Hranjec, Marijana
engleski
Synthesis and antiproliferative activity of novel 2-substituted N-methylated benzimidazoles and tetracyclic benzimidazo[1,2-a]quinolines
In this manuscript, the synthesis, antiproliferative activity in vitro and structure-activity relationship of N-methylated 2-benzimidazoles related to 2, 3-acrylonitriles and benzimidazo[1, 2-a]quinolines bearing halogeno or amino substituent is described. Amino substituted N-methylated benzimidazo[1, 2-a]quinolines were prepared by using microwave assisted amination from corresponding halogeno substituted precursors. All newly prepared compounds were tested against tree human cancer cells to assess their antiproliferative activity in vitro. Compounds 4a and 4b display certain selective activity against MCF-7 cells together with the N, N-dimethylamino substituted derivative 4e with IC50 0.4 µM. Cyclic derivatives 7a, 7b and 8 were more active with IC50 in micromolar range of concentrations but without any selectivity among tested cells. Among the most active compounds, 2-amino substituted derivatives 9a and 9b were also selective against HCT116 cells with IC50 values 0.2 µM and 0.4 µM, respectively. The influence of compounds 9a and 9b on the cell cycle of HCT 116 revealed that both compounds induced a strong reduction of the percentage of cells in S phase, along with the induction of cell death.
benzimidazoles ; benzimidazo[1 ; 2-a]quinolines ; antiproliferative activity in vitro ; SAR ; fluorescence microscopy
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Podaci o izdanju
40 (2)
2020.
343-354
objavljeno
1040-6638
1563-5333
10.1080/10406638.2018.1441877
Povezanost rada
Kemija, Temeljne medicinske znanosti