engleski

Pyrazole nucleus fused tri-substituted imidazole derivatives as antioxidant and antibacterial agents

A novel series of tri-substituted imidazole derivatives were synthesized according to well- known Radziszewski reaction. Desired molecules were obtained in reaction of benzil, ammonium acetate and different derivatives of 1H- pyrazole-4-carbaldehyde. Structures of synthesized entities were confirmed with the support of modern techniques like elemental analysis (CHN) and spectral analysis (FTIR, 1H- and 13C-NMR and LC–MS). All compounds were screened for their biological potency like: antibacterial activity using serial broth dilution method and antioxidant activity using DPPH method. Antimicrobial activity was performed against Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa). The title compounds showed moderate to excellent antimicrobial and antioxidant potency against different bacterial strains and DPPH radical.

benzil ; substituted 1H-pyrazole-4-carbaldehyde ; Radziszewski reaction ; antibacterial activity ; antioxidant activity

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