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Pregled bibliografske jedinice broj: 917524

Halohydrin dehalogenase-catalysed transformations of epifluorohydrin


Majerić Elenkov, Maja; Čičak, Mirjana; Knežević, Anamarija; Smolko, Ana
Halohydrin dehalogenase-catalysed transformations of epifluorohydrin // Tetrahedron letters, 59 (2018), 4; 406-408 doi:10.1016/j.tetlet.2017.12.054 (međunarodna recenzija, kratko priopcenje, znanstveni)


Naslov
Halohydrin dehalogenase-catalysed transformations of epifluorohydrin

Autori
Majerić Elenkov, Maja ; Čičak, Mirjana ; Knežević, Anamarija ; Smolko, Ana

Izvornik
Tetrahedron letters (0040-4039) 59 (2018), 4; 406-408

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
Biocatalysis ; Halohydrin dehalogenase ; Epoxide ring-opening ; Epifluorohydrin ; Fluoro alcohols

Sažetak
Biocatalytic ring-opening of epifluorohydrin has been performed by using halohydrin dehalogenase. The enzyme from Mycobacterium sp. GP1 (HheB2) catalysed reaction with high regioselectivity and low enantioselectivity in the presence of different nucleophiles, producing racemic 1-substituted 3-fluoro-2-propanols. No by-products resulting from the ring-closure reaction have been detected, confirming that vicinal fluoro alcohols are not substrates for HHDH. Four different 3-fluoro-2-propanols were prepared under mild reaction conditions starting from epifluorohydrin. High conversions of 85-100% were reached within 1-3h and depending on the nucleophile used products were isolated in 31-92% yields.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

Napomena
Reaxys ; Current Contents Search ; Derwent Drug File ; Pascal ; Research Alert ; SciSearch



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb,
Strojarski fakultet, Slavonski Brod

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Arts & Humanities Citation Index (A&HCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka:


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  • CA Search (Chemical Abstracts)
  • CAB Abstracts
  • Chemical Engineering and Biotechnology Abstracts
  • Compendex (EI Village)
  • Current Biotechnology Abstracts
  • EMBASE (Excerpta Medica)
  • Reaxys
  • Current Contents Search
  • Derwent Drug File
  • Pascal
  • Research Alert
  • SciSearch


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