engleski

Persistence of humoral immunity to rabies 1100 days after immunization and effect of a single booster dose of rabies vaccine

Forty-four vaccinees immunized with rabies vaccine and human rabies immunoglobulin according to the abbreviated intramuscular regimen (the 2-1-1 schedule) were followed-up after 1100 days and had their blood samples taken. The persistence of rabies neutralizing antibody was proven in the sera of all vaccinees, 56% of whom demonstrated titres ⩾0.5 IU ml−1. At the same day the vaccinees were given a single booster dose of vaccine whose effect was measured 2 weeks later. With the RFFI test on day 1114, sera revealed an extraordinarily high booster response in all 44 vaccinees. The study proved the anamnestic response after a full course of rabies vaccination to be a very stable one, and the capability of a single booster dose of vaccine to evoke high-titred rabies antibody response. Of the four vaccines used in the study, under comparable conditions, HDCV proved superior to PCECV, PDEV and PVRV on all 3 days of serology— 35, 1100 and 1114, though this difference was statistically attested only on days 35 and 1114.

rabies, vaccination, clinical trial, immunity, antibody persistence

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