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Pregled bibliografske jedinice broj: 916945

DNA–Protein Crosslink Proteolysis Repair


Vaz, Bruno; Popović, Marta; Ramadan, Kristijan
DNA–Protein Crosslink Proteolysis Repair // Trends in biochemical sciences, 42 (2017), 6; 483-495 doi:10.1016/j.tibs.2017.03.005 (međunarodna recenzija, pregledni rad, stručni)


Naslov
DNA–Protein Crosslink Proteolysis Repair

Autori
Vaz, Bruno ; Popović, Marta ; Ramadan, Kristijan

Izvornik
Trends in biochemical sciences (0968-0004) 42 (2017), 6; 483-495

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
Aging, cancer, DNA–protein crosslink, DNA–protein crosslink proteolysis repair, DNA replication, genome stability, SPARTAN (DVC1) protease, Wss1 protease

Sažetak
Proteins that are covalently bound to DNA constitute a specific type of DNA lesion known as DNA–protein crosslinks (DPCs). DPCs represent physical obstacles to the progression of DNA replication. If not repaired, DPCs cause stalling of DNA replication forks that consequently leads to DNA double-strand breaks, the most cytotoxic DNA lesion. Although DPCs are common DNA lesions, the mechanism of DPC repair was unclear until now. Recent work unveiled that DPC repair is orchestrated by proteolysis performed by two distinct metalloproteases, SPARTAN in metazoans and Wss1 in yeast. This review summarizes recent discoveries on two proteases in DNA replication-coupled DPC repair and establishes DPC proteolysis repair as a separate DNA repair pathway for genome stability and protection from accelerated aging and cancer.

Izvorni jezik
Engleski



POVEZANOST RADA


Citiraj ovu publikaciju

Vaz, Bruno; Popović, Marta; Ramadan, Kristijan
DNA–Protein Crosslink Proteolysis Repair // Trends in biochemical sciences, 42 (2017), 6; 483-495 doi:10.1016/j.tibs.2017.03.005 (međunarodna recenzija, pregledni rad, stručni)
Vaz, B., Popović, M. & Ramadan, K. (2017) DNA–Protein Crosslink Proteolysis Repair. Trends in biochemical sciences, 42 (6), 483-495 doi:10.1016/j.tibs.2017.03.005.
@article{article, year = {2017}, pages = {483-495}, DOI = {10.1016/j.tibs.2017.03.005}, keywords = {aging, cancer, DNA–protein crosslink, DNA–protein crosslink proteolysis repair, DNA replication, genome stability, SPARTAN (DVC1) protease, Wss1 protease}, journal = {Trends in biochemical sciences}, doi = {10.1016/j.tibs.2017.03.005}, volume = {42}, number = {6}, issn = {0968-0004}, title = {DNA–Protein Crosslink Proteolysis Repair}, keyword = {aging, cancer, DNA–protein crosslink, DNA–protein crosslink proteolysis repair, DNA replication, genome stability, SPARTAN (DVC1) protease, Wss1 protease} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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