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Pregled bibliografske jedinice broj: 916581

Predictive value of intraoperative sentinel lymph node imprint cytology analysis for metastasis in patients with melanoma


Jonjić, Nives; Rajković Molek, Koraljka; Seili-Bekafigo, Irena; Grbac-Ivanković, Svjetlana; Girotto, Neva; Jurišić, Davor; Zamolo, Gordana; Pavlović-Ružić, Ira; Prpić- Massari, Larisa
Predictive value of intraoperative sentinel lymph node imprint cytology analysis for metastasis in patients with melanoma // Acta dermatovenerologica Croatica, 25 (2017), 2; 99-106 (recenziran, članak, znanstveni)


CROSBI ID: 916581 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Predictive value of intraoperative sentinel lymph node imprint cytology analysis for metastasis in patients with melanoma
(Predictive Value of Intraoperative Sentinel Lymph Node Imprint Cytology Analysis for Metastasis in Patients with Melanoma)

Autori
Jonjić, Nives ; Rajković Molek, Koraljka ; Seili-Bekafigo, Irena ; Grbac-Ivanković, Svjetlana ; Girotto, Neva ; Jurišić, Davor ; Zamolo, Gordana ; Pavlović-Ružić, Ira ; Prpić- Massari, Larisa

Izvornik
Acta dermatovenerologica Croatica (1330-027X) 25 (2017), 2; 99-106

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
sentinel lymph node biopsy, touch imprint cytology, melanoma, intraoperative

Sažetak
Since there are no standardized protocols regarding the detection of microscopic melanoma deposits in sentinel lymph nodes (SLN), the aim of this study was to present our experience with intraoperative cytological evaluation of SLN in patients with melanoma. The study included 475 SLN biopsies (SLNB) from 201 patients with primary cutaneous melanoma of intermediate thickness. Each lymph node was cut in half ; touch imprint cytology (TIC) preparations of all cut surfaces were performed and stained according to a modified May- Grünwald-Giemsa method. The results were compared to definitive postoperative histology. Twenty of 25 SLNB positive on TIC proved to be metastatic when compared to definitive histology. Most of 32 SLN that were suspicious but not diagnostic on TIC were proven negative (23/32, 71.8%), while 7 nodes had metastases (one micrometastasis and one with isolated tumor cells only). The majority (94%) of SLNBs negative on TIC remained negative on final histology, while 6% or 25 nodes were positive, mostly with micrometastases or isolated tumor cells (17/25). In frozen sections performed in cases of suspicious or positive SLN cytology, metastasis was confirmed in 80% of positive and in 21.9% of suspicious TIC. Altogether, 49% (27/55) of positive SLNB were identified intraoperatively in 57% (24/42) of patients, and in those cases a complete regional lymph node dissection was performed in the first step. TIC assessment of SLNB with 99% specificity and 57% sensitivity for intraoperative identification of metastasis is useful and beneficial for avoiding a second operative procedure.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Citiraj ovu publikaciju

Jonjić, Nives; Rajković Molek, Koraljka; Seili-Bekafigo, Irena; Grbac-Ivanković, Svjetlana; Girotto, Neva; Jurišić, Davor; Zamolo, Gordana; Pavlović-Ružić, Ira; Prpić- Massari, Larisa
Predictive value of intraoperative sentinel lymph node imprint cytology analysis for metastasis in patients with melanoma // Acta dermatovenerologica Croatica, 25 (2017), 2; 99-106 (recenziran, članak, znanstveni)
Jonjić, N., Rajković Molek, K., Seili-Bekafigo, I., Grbac-Ivanković, S., Girotto, N., Jurišić, D., Zamolo, G., Pavlović-Ružić, I. & Prpić- Massari, L. (2017) Predictive value of intraoperative sentinel lymph node imprint cytology analysis for metastasis in patients with melanoma. Acta dermatovenerologica Croatica, 25 (2), 99-106.
@article{article, year = {2017}, pages = {99-106}, keywords = {sentinel lymph node biopsy, touch imprint cytology, melanoma, intraoperative}, journal = {Acta dermatovenerologica Croatica}, volume = {25}, number = {2}, issn = {1330-027X}, title = {Predictive Value of Intraoperative Sentinel Lymph Node Imprint Cytology Analysis for Metastasis in Patients with Melanoma}, keyword = {sentinel lymph node biopsy, touch imprint cytology, melanoma, intraoperative} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE