engleski

Hepatitis B and C serological profiles of liver/kidney donors and recipients: 10-year Croatian single centre analysis

Introduction: Screening for hepatitis B (HBV) and hepatitis C (HCV) viruses is a requirement in organ transplantation. The information acquired influences organ allocation and post-transplant management. The goal of this review was to determine HBV and HCV serological profiles of liver and kidney donors and recipients. Methods: HBV and HCV serologies were retrospectively obtained for adult liver and kidney recipients and their donors between 6/2006 and 6/2016 using a hospital transplant database. Results: In total 1308 serological profiles of organ recipients and their donors were analyzed. There were 452 kidney (65% male, mean age 49.5 _12.5 years.) and 856 liver recipients (72% male, mean age 55.1 _ 10.4 years). 1.5% kidney and 5.4% liver recipients were hepatitis B surface antigen (HBsAg) positive. 34.5% of kidney and 69.7% of liver recipients were non-immune to HBV. The prevalence of successful pre-transplant HBV vaccine immunity was greater in kidney than in liver recipients (36.9% vs 5.5%). 2.2% of kidney and 3.4% of liver recipients were only HBcAb positive. HBV vaccine immunity of both organ recipient groups did not change significantly during period of 10 years (p = ns). There were 2.2% kidney and 15.7% liver HCV antibody positive recipients. 1.1% of kidney and 0.2% of liver recipients were both HBsAg and HCVAb positive. From the total number of kidney grafts, 8.85% were HBcAb positive and no kidney grafts were HBsAg or anti-HCV positive. From the total number of liver grafts 7.7% were HBcAb, 0.1% HBsAg and 0.2% HCVAb positive. Conclusion: The prevalence of HBV and HCV HBV co-infection in organ recipients is low, as well as the prevalence of anti-HCV in kidney patients at the time of transplant. HBV immunity in the pre-transplant liver kidney cohort is low and has not changed significantly in the observed period. This analysis indicates that greater efforts should be implemented in the pre-transplant vaccination process.

liver/kidney transplantation ; seroprevalence of HBV and HCV in organ donors and recipients

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