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Pregled bibliografske jedinice broj: 915319

Surface coating affects uptake of silver nanoparticles in neural stem cells


Pongrac, Igor M.; Brkić Ahmed, Lada; Mlinarić, Hrvoje; Domazet Jurašin, Darija; Pavičic, Ivan; Marjanović Čermak, Ana Marija; Milić, Mirta; Gajović, Srećko; Vinković Vrček, Ivana
Surface coating affects uptake of silver nanoparticles in neural stem cells // Journal of trace elements in medicine and biology, 50 (2018), 684-692 doi:10.1016/j.jtemb.2017.12.003 (međunarodna recenzija, članak, znanstveni)


Naslov
Surface coating affects uptake of silver nanoparticles in neural stem cells

Autori
Pongrac, Igor M. ; Brkić Ahmed, Lada ; Mlinarić, Hrvoje ; Domazet Jurašin, Darija ; Pavičic, Ivan ; Marjanović Čermak, Ana Marija ; Milić, Mirta ; Gajović, Srećko ; Vinković Vrček, Ivana

Izvornik
Journal of trace elements in medicine and biology (0946-672X) 50 (2018); 684-692

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Silver nanoparticles ; Surface coating ; Cellular uptake ; Cytotoxicity ; Neural stem cells

Sažetak
The rapid development and widespread applications of nanotechnology necessitates the design towards safe nanoparticles. Surface structure is among the most important physicochemical characteristics of metallic nanoparticles affecting their mode of action in certain biological or environmental compartments. This study aimed to investigate how different surface coatings affect the cytotoxicity and cellular uptake of silver nanoparticles (AgNPs) in murine neural stem cells (mNSCs). Different AgNPs were prepared by stabilisation with surface coatings encompassing sodium bis(2-ethylhexyl)-sulfosuccinate (AOT), cetyltrimethylammonium bromide (CTAB), poly(vinylpyrrolidone) (PVP), poly-l-lysine (PLL), and bovine serum albumin (BSA). The obtained results revealed that AgNPs stabilized with different surface coating caused different cytotoxicity effects and internalization pattern in mNSCs. Macropinocytosis was determined as the main uptake mechanism in mNSCs for all of the tested AgNP types. These findings contribute to the overall knowledge essential to the safety assessment of novel nanomaterials.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2016-06-2436 - Značaj interakcija metalnih nanočestica sa sumpornim biomolekulama za nano-bio sučelje (Ivana Vinković Vrček, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Pongrac, Igor M.; Brkić Ahmed, Lada; Mlinarić, Hrvoje; Domazet Jurašin, Darija; Pavičic, Ivan; Marjanović Čermak, Ana Marija; Milić, Mirta; Gajović, Srećko; Vinković Vrček, Ivana
Surface coating affects uptake of silver nanoparticles in neural stem cells // Journal of trace elements in medicine and biology, 50 (2018), 684-692 doi:10.1016/j.jtemb.2017.12.003 (međunarodna recenzija, članak, znanstveni)
Pongrac, I., Brkić Ahmed, L., Mlinarić, H., Domazet Jurašin, D., Pavičic, I., Marjanović Čermak, A., Milić, M., Gajović, S. & Vinković Vrček, I. (2018) Surface coating affects uptake of silver nanoparticles in neural stem cells. Journal of trace elements in medicine and biology, 50, 684-692 doi:10.1016/j.jtemb.2017.12.003.
@article{article, year = {2018}, pages = {684-692}, DOI = {10.1016/j.jtemb.2017.12.003}, keywords = {Silver nanoparticles, Surface coating, Cellular uptake, Cytotoxicity, Neural stem cells}, journal = {Journal of trace elements in medicine and biology}, doi = {10.1016/j.jtemb.2017.12.003}, volume = {50}, issn = {0946-672X}, title = {Surface coating affects uptake of silver nanoparticles in neural stem cells}, keyword = {Silver nanoparticles, Surface coating, Cellular uptake, Cytotoxicity, Neural stem cells} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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