Mechanisms of fetal epigenetics that determine telomere dynamics and health span in adulthood (CROSBI ID 246024)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
Ravlić, Sanda ; Škrobot Vidaček, Nikolina ; Nanić, Lucija ; Laganović, Mario ; Slade, Neda ; Jelaković, Bojan ; Rubelj, Ivica
engleski
Mechanisms of fetal epigenetics that determine telomere dynamics and health span in adulthood
Advances in epigenetics now enable us to better understand environmental influences on the genetic background of human diseases. This refers especially to fetal development where an adverse intrauterine environment impacts oxygen and nutrient supply to the fetus. Recently, differences in telomere length and telomere loss dynamics among individuals born with intrauterine growth restriction compared to normal controls have been described. In this paper we propose possible molecular mechanisms that (pre)program telomere epigenetics during pregnancy. This programming sets differences in telomere lengths and dynamics of telomere shortening in adulthood and therefore dictates the dynamics of aging and morbidity in later life.
epigenetics ; telomeres ; foetal development ; cardiovascular diseases
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
174
2018.
55-62
objavljeno
0047-6374
1872-6216
10.1016/j.mad.2017.08.014
Povezanost rada
Biologija, Temeljne medicinske znanosti