engleski

Comminution kinetics of α and γ-glycine polymorphs in a planetary ball mill

Glycine is the important amino acid that functions as inhibitory neurotransmitter and therefore has been a topic of many researches. This work deals with modeling of the comminution process for glycine crystals. Three different glycine samples (two γ and one α form) were prepared by batch cooling crystallization and afterwards comminuted in a planetary ball mill. Comminution kinetics was investigated using the analytical solution of population balance. Crystal size distribution was expressed with Sauter's mean diameter and modeled using simple first-order breakage kinetic with a milling limit. Results showed the obtained models can be used to predict crystal size distribution during the comminution process. PXRD analysis showed there was no mechanically induced solid-state polymorphic phase transformation of glycine.

Glycine, Crystal Size Distribution, Comminution Kinetics, Population Balance, Polymorph

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