engleski

Leber's Hereditary Optic Neuropathy. A Case Report

LHON is characterized by bilateral asynchronous visual loss in young adults. This type of neuropathy is related to mitochondrial DNA mutation and therefore is maternally inherited. Males are predominantly affected but they do not transmit the disease to their offspring. Clinical picture - although characteristic - is not impressive. At the beginning of the disease, there is a large discrepancy between the symptoms and signs. In contrast to marked central visual loss, the only visible sign is retinal teleangiectatic microangiopathy in the peripapillary region. Fluorescein angiography shows intact capillary network without leakage disproving its inflammatory nature.

Hereditary optic atrophy ; mitochondrial DNA mutation

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