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Pregled bibliografske jedinice broj: 913178

Diclofenac sodium versus placebo for unsedated colonoscopy in hospitalized patients: a randomised, double-blind, placebo controlled study


Giljača, Vanja; Dorčić, Gordan; Hauser, Goran; Salkić, Nermina; Štimac, Davor
Diclofenac sodium versus placebo for unsedated colonoscopy in hospitalized patients: a randomised, double-blind, placebo controlled study // Gut, 66 (2017) S2
Manchester ; Velika Britanija: British Society of Gastroenterology, 2017. str. 220-220 doi:10.1136/gutjnl-2017-314472.427 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Diclofenac sodium versus placebo for unsedated colonoscopy in hospitalized patients: a randomised, double-blind, placebo controlled study

Autori
Giljača, Vanja ; Dorčić, Gordan ; Hauser, Goran ; Salkić, Nermina ; Štimac, Davor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Gut, 66 (2017) S2 / - : British Society of Gastroenterology, 2017, 220-220

Skup
Annual General Meeting of The British Society of Gastroenterology

Mjesto i datum
Manchester ; Velika Britanija, 19.–22.06.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Diclophenac sodium, colonoscopy

Sažetak
Abstract Introduction Patients rarely accept colonoscopy without anxiety because the procedure is commonly associated with significant pain (1). Different agents were investigated to increase patient comfort and technical performance of colonoscopy with variable success and adverse events profiles (2). Diclofenac inhibited visceral pain signals on colonic stretching in animal studies (3). Method We have conducted a single-centre randomised study to evaluate the analgesic effect of diclofenac versus placebo in patients undergoing unsedated colonoscopy. Patients were randomised to receive 100 mg of diclofenac (Group 1) or placebo (Group 2). We used a 10- point VAS scale for pain. Mann-Whitney test was used to compare mean pain index and time to discharge. Spearman’s test was used for correlation between caecal intubation rates and pain. Results We recruited a total of 88 patients divided into 2 groups: 43 (48.9%) in intervention group and 45 (51.1%) into placebo group. Baseline characteristics of patients did not differ significantly. There was no difference between groups in pain during colonoscopy (Mann-Whitney ; Z=−0.84 ; p=0.40) or in grading of colonoscopy experience (1–10 scale) (Mann-Whitney ; Z=−0.99 ; p=0.32), or number of patients that would repeat colonoscopy. There wasn’t any significant correlation between caecal intubation time and pain scale values (Spearman’s r=0.17 ; p=0.20). A significant correlation between caecal intubation time and pain scale values was found in placebo group (Spearman’s r=0.37 ; p=0.04) but not in intervention group (Spearman’s r=−0.08 ; p=0.71). Two lethal outcomes were recorded, both in the placebo group (4.4% ; p=0.50%). Time to discharge in days was also not significantly different (Mann Whitney ; Z=−0.18 ; p=0.85).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka,
Fakultet zdravstvenih studija u Rijeci

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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