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Autoantibodies to Asialoglycoprotein receptor (ASGPR) in children with autoimmune hepatitis


Tešija Kuna, Andrea; Žaja Franulović, Orjena; Jaklin Kekez, Alemka; Vukasović, Ines; Vrkić, Nada
Autoantibodies to Asialoglycoprotein receptor (ASGPR) in children with autoimmune hepatitis // Autoimmunity 2012 ; 52 (Suppl 2)
Granada, Španjolska, 2012. S 104, 1 doi:10.13140/2.1.3932.9605. (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Autoantibodies to Asialoglycoprotein receptor (ASGPR) in children with autoimmune hepatitis

Autori
Tešija Kuna, Andrea ; Žaja Franulović, Orjena ; Jaklin Kekez, Alemka ; Vukasović, Ines ; Vrkić, Nada

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Autoimmunity 2012 ; 52 (Suppl 2) / - , 2012

Skup
The 8th International Congress on Autoimmunity

Mjesto i datum
Granada, Španjolska, 09-13.05.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Autoimmune hepatitis, children, autoantibodies, ASPGR

Sažetak
Background: Autoantibodies to liver-specific asialoglycoprotein receptor (ASGPR) has been suggested as a relevant serologic marker of autoimmune hepatitis (AIH) showing a correlation with disease activity. Recently, a novel ELISA anti-ASGPR assay (Generic Assays GmbH, Germany) has been shown to detect readily anti-ASGPR with higher specificity in comparison to assays available so far. Aim: To evaluate the significance of anti-ASGPR in children with autoimmune hepatitis. Patients and methods: Anti-ASGPR IgG was measured by novel ELISA in sera of 55 children (27 girls, 28 boys, mean age 14.4 ± 3.5 years). Eleven children were diagnosed with AIH and control group included celiac disease (CD) (N=18), fatty liver (N=17), other (N=9). Anti-ASGPR was correlated with biochemical parameters of disease activity. One newly diagnosed AIH patient was followed over treatment period of 2 years. Results: Anti-ASGPR were positive in 2/11 AIH patients and in 3/44 controls, all three with CD. One anti-ASGPR positive AIH patient was a boy with newly discovered, non-treated highly active disease and the other had poorly controlled AIH type II. All but one of other AIH patients had a well controlled disease. Anti-ASGPR positive CD patients had a history of recent EBV infection in one, overlap with other autoimmune diseases in second and recent gluten provocation diet in the third case. In newly discovered AIH patient anti- ASGPR status correlated with disease activity during 2 years follow up. Conclusion: Our results confirmed the association of anti-ASGPR with more severe AIH and possible role in monitoring disease activity.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Stomatološki fakultet, Zagreb,
Zdravstveno veleučilište, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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