Autoantibodies to Asialoglycoprotein receptor (ASGPR) in children with autoimmune hepatitis (CROSBI ID 656451)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Tešija Kuna, Andrea ; Žaja Franulović, Orjena ; Jaklin Kekez, Alemka ; Vukasović, Ines ; Vrkić, Nada
engleski
Autoantibodies to Asialoglycoprotein receptor (ASGPR) in children with autoimmune hepatitis
Background: Autoantibodies to liver-specific asialoglycoprotein receptor (ASGPR) has been suggested as a relevant serologic marker of autoimmune hepatitis (AIH) showing a correlation with disease activity. Recently, a novel ELISA anti-ASGPR assay (Generic Assays GmbH, Germany) has been shown to detect readily anti-ASGPR with higher specificity in comparison to assays available so far. Aim: To evaluate the significance of anti-ASGPR in children with autoimmune hepatitis. Patients and methods: Anti-ASGPR IgG was measured by novel ELISA in sera of 55 children (27 girls, 28 boys, mean age 14.4 ± 3.5 years). Eleven children were diagnosed with AIH and control group included celiac disease (CD) (N=18), fatty liver (N=17), other (N=9). Anti-ASGPR was correlated with biochemical parameters of disease activity. One newly diagnosed AIH patient was followed over treatment period of 2 years. Results: Anti-ASGPR were positive in 2/11 AIH patients and in 3/44 controls, all three with CD. One anti-ASGPR positive AIH patient was a boy with newly discovered, non-treated highly active disease and the other had poorly controlled AIH type II. All but one of other AIH patients had a well controlled disease. Anti-ASGPR positive CD patients had a history of recent EBV infection in one, overlap with other autoimmune diseases in second and recent gluten provocation diet in the third case. In newly discovered AIH patient anti- ASGPR status correlated with disease activity during 2 years follow up. Conclusion: Our results confirmed the association of anti-ASGPR with more severe AIH and possible role in monitoring disease activity.
autoimmune hepatitis, children, autoantibodies, ASPGR
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Podaci o prilogu
S 104
2012.
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objavljeno
10.13140/2.1.3932.9605.
Podaci o matičnoj publikaciji
Autoimmunity
0891-6934
1607-842X
Podaci o skupu
The 8th International Congress on Autoimmunity
poster
09.05.2012-13.05.2012
Granada, Španjolska
Povezanost rada
Kliničke medicinske znanosti