engleski

Bone mineral status in adolescent female patients with anorexia nervosa

Objectives and Study: Eating disorders are the third most common chronic disease in adolescents. The number of adolescents with eating disorders is increasing continuously. In essence, anorexia nervosa (AN) is a psycho- emotional disorder. The malnutrition that develops as an outcome in AN carries great risks of different physical complications with permanent consequences. The development of anorexia nervosa in the very sensitive period of adolescence, when the majority of bone mass is gained, can result in low bone mineral density and development of osteoporosis. The aim of this study was to evaluate the level of bone mineral density (BMD), serum values of insulin-like growth hormone (IGF-I), bone markers (osteocalcin-OC and C-telopeptid of type I collagen-CTX) and their relationships with the duration of the disease and the duration of amenorrhea. Methods: We examined 90 adolescent girls with AN mean age 15.4±2.9 years (8.11-21.7), 69 of them with secondary amenorrhea (SA) average duration 8, 8±10.18 months (2-49) and the rest of them with primary amenorrhea. According to the duration of the disease the patients were divided into two groups. Group A (≤12 months) and Group B (>12 months). We used the Pearson linear correlation test to compare the two groups. Results: We found significant negative correlations between the level of Z-score and the duration of the disease (r= - 0, 257 ; p=0, 0149), between the level of Z-score and the duration of amenorrhea (r= -0, 385, p=0, 0011) in the group of girls with SA and negative correlation between IGF-I and bone resorption markers serum values (r= -0, 49 ; p=0, 008). Concentration of bone markers, IGF-I and body mass index did not differ significantly among the groups. Conclusion: The disease duration as well as the duration of amenorrha significantly affected bone mineral density. Lower IGF-I concentrations correlated with higher bone resorption markers and decreased mineralization, which suggests the importance of IGF-I in the ethiolopathogenesis of osteoporosis. No difference was ascertained in the values of bone markers, which could potentially be the result of a significant age difference among the groups.

anorexia nervosa ; childen ; bone density

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