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The Effect of Short-Toothed and Dalmatian Sage Extracts on Platelet Aggregation

Sage (Salvia) is genus of native Mediterranean plant used for aromatization of foods. In this study total polyphenol profile, antioxidant properties and antiplatelet effect of short- toothed sage (Salvia brachyodon Vandas) are analyzed and compared to most commonly used Salvia species (S. officinalis, Dalmatian sage). Content of total flavonoids was 0.08- 0.23 % and of phenolic acids 0.47-3.04 %. Antioxidant DPPH assay showed higher antioxidant capacity of S. brachyodon (29-36 mg/mL of gallic acid equivalents) compared to S. officinalis. In functional test of primary hemostasis extracts of S. brachyodon have prevented platelet aggregation in nanomolar concentration (21 nM) thus showing potential in prevention of thrombus formation as functional food or dietary supplement. Antiplatelet activity was related to antioxidant capacity (r = 0.7014, p = 0.0352) indicating that prevention of aggregation is not caused by individual component rather it is result of synergistic effect of polyphenols. The obtained results are preliminary and a more detailed study of the possibility of applying the investigated plant species as supplements for the prevention of the problem of cardiovascular system and platelet aggregation is needed.

sage ; flavonoids ; phenolic acids ; platelet aggregation

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