engleski

Synthesis and Antitumor Activities of Novel Pyrimidine Derivatives of 2, 3-O, O-Dibenzyl-6-deoxy-L-ascorbic Acid and 4, 5-Didehydro-5, 6-dideoxy-L-ascorbic Acid

SAR studies of title derivatives (I) and (II), concerning their antiviral and antitumor activity, reveal that none of the compounds shows appreciable antiviral activity, but that compound (IIb) exhibits significant antitumor cell activity, particularly against murine leukemia L1210/0, murine mammary carcinoma FM3A/0, and, to a lesser extent, human T-lymphocyte cells Molt4/C8 and CEM/0 cell lines. The Z-configuration of the C-4’–C-5’ double bond and the position of the benzyl group in the lactone ring of derivative (IId) are determined by 1H and 13C NMR, COSY, ROESY, and HMBC spectroscopic analyses.

pyrimidine, ascorbic acid, NMR

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