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Pregled bibliografske jedinice broj: 911063

IgG glycosylation and DNA methylation are interconnected with smoking


Wahl, Annika; Kasela, Silva; Monotoro, Elena Carnero; van Iterson, Maarten; Štambuk, Jerko; Sharma, Sapna; van den Akker, Erik; Klaric, Lucija; Benedetti, Elisa; Razdorov, Genadij et al.
IgG glycosylation and DNA methylation are interconnected with smoking // Biochimica et biophysica acta. G, General subjects, 1862 (2018), 3; 637-648 doi:10.1016/j.bbagen.2017.10.012 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 911063 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
IgG glycosylation and DNA methylation are interconnected with smoking

Autori
Wahl, Annika ; Kasela, Silva ; Monotoro, Elena Carnero ; van Iterson, Maarten ; Štambuk, Jerko ; Sharma, Sapna ; van den Akker, Erik ; Klaric, Lucija ; Benedetti, Elisa ; Razdorov, Genadij ; Trbojević-Akmačić, Irena ; Vučković, Frano ; Ugrina, Ivo ; Beekman, Marian ; Deelen, Joris ; van Heemst, Diana ; Heijmans, Bastiaan T. ; Consortium, B.I.O.S. ; Wuhrer, Manfred ; Plomp, Rosina ; Keser, Toma ; Šimurina, Mirna ; Pavić, Tamara ; Gudelj, Ivan ; Krištić, Jasminka ; Grallert, Harald ; Kunze, Sonja ; Peters, Annette ; Bell, Jordana T. ; Spector, Timothy D. ; Milani, Lili ; Eline Slagboom, P. ; Lauc, Gordan ; Gieger, Christian

Izvornik
Biochimica et biophysica acta. G, General subjects (0304-4165) 1862 (2018), 3; 637-648

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DNA methylation ; IgG glycosylation ; Smoking ; EWAS ; Mediation

Sažetak
Background: Glycosylation is one of the most common post- translation modifications with large influences on protein structure and function. The effector function of immunoglobulin G (IgG) alters between pro- and anti-inflammatory, based on its glycosylation. IgG glycan synthesis is highly complex and dynamic. Methods: With the use of two different analytical methods for assessing IgG glycosylation, we aim to elucidate the link between DNA methylation and glycosylation of IgG by means of epigenome- wide association studies. In total, 3000 individuals from 4 cohorts were analyzed. Results: The overlap of the results from the two glycan measurement panels yielded DNA methylation of 7 CpG-sites on 5 genomic locations to be associated with IgG glycosylation: cg25189904 (chr.1, GNG12) ; cg05951221, cg21566642 and cg01940273 (chr.2, ALPPL2) ; cg05575921 (chr.5, AHRR) ; cg06126421 (6p21.33) ; and cg03636183 (chr.19, F2RL3). Mediation analyses with respect to smoking revealed that the effect of smoking on IgG glycosylation may be at least partially mediated via DNA methylation levels at these 7 CpG-sites. Conclusion: Our results suggest the presence of an indirect link between DNA methylation and IgG glycosylation that may in part capture environmental exposures. General significance: An epigenome-wide analysis conducted in four population-based cohorts revealed an association between DNA methylation and IgG glycosylation patterns. Presumably, DNA methylation mediates the effect of smoking on IgG glycosylation.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Farmacija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
GENOS d.o.o.,
Sveučilište u Zagrebu

Citiraj ovu publikaciju

Wahl, Annika; Kasela, Silva; Monotoro, Elena Carnero; van Iterson, Maarten; Štambuk, Jerko; Sharma, Sapna; van den Akker, Erik; Klaric, Lucija; Benedetti, Elisa; Razdorov, Genadij et al.
IgG glycosylation and DNA methylation are interconnected with smoking // Biochimica et biophysica acta. G, General subjects, 1862 (2018), 3; 637-648 doi:10.1016/j.bbagen.2017.10.012 (međunarodna recenzija, članak, znanstveni)
Wahl, A., Kasela, S., Monotoro, E., van Iterson, M., Štambuk, J., Sharma, S., van den Akker, E., Klaric, L., Benedetti, E. & Razdorov, G. (2018) IgG glycosylation and DNA methylation are interconnected with smoking. Biochimica et biophysica acta. G, General subjects, 1862 (3), 637-648 doi:10.1016/j.bbagen.2017.10.012.
@article{article, year = {2018}, pages = {637-648}, DOI = {10.1016/j.bbagen.2017.10.012}, keywords = {DNA methylation, IgG glycosylation, Smoking, EWAS, Mediation}, journal = {Biochimica et biophysica acta. G, General subjects}, doi = {10.1016/j.bbagen.2017.10.012}, volume = {1862}, number = {3}, issn = {0304-4165}, title = {IgG glycosylation and DNA methylation are interconnected with smoking}, keyword = {DNA methylation, IgG glycosylation, Smoking, EWAS, Mediation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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  • EMBiology
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