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Pregled bibliografske jedinice broj: 909279

The Effects of Electroconvulsive Therapy Augmentation of Antipsychotic Treatment on Cognitive Functions in Patients With Treatment-Resistant Schizophrenia


Vuksan Ćusa, Bjanka; Klepac, Nataša; Jakšić, Nenad, Bradaš, Zoran; Božičević, Marija; Palac, Nataša; Šagud, Marina
The Effects of Electroconvulsive Therapy Augmentation of Antipsychotic Treatment on Cognitive Functions in Patients With Treatment-Resistant Schizophrenia // Journal of ect, [Epub ahead of print] (2017), [Epub ahead of print; 29053485, 5 doi:10.1097/YCT.0000000000000463 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 909279 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The Effects of Electroconvulsive Therapy Augmentation of Antipsychotic Treatment on Cognitive Functions in Patients With Treatment-Resistant Schizophrenia

Autori
Vuksan Ćusa, Bjanka ; Klepac, Nataša ; Jakšić, Nenad, Bradaš, Zoran ; Božičević, Marija ; Palac, Nataša ; Šagud, Marina

Izvornik
Journal of ect (1095-0680) [Epub ahead of print] (2017), [Epub ahead of print; 29053485, 5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
schizophrenia, cognitive functions, electroconvulsive therapy, ECT, memory

Sažetak
OBJECTIVES: Treatment-resistant schizophrenia (TRS) continues to be a challenge in modern psychiatry. Most of these patients have severe neurocognitive deficits. Electroconvulsive therapy (ECT) has proved effective and safe in the treatment of TRS, but because of potential neurocognitive adverse effects, it is associated with many controversies. The aim of this prospective, open study was to evaluate the effects of ECT augmentation of antipsychotics on cognitive functions in patients with TRS. METHODS: Overall, 31 inpatients with TRS were included, 16 men, with an average (SD) age of 34.1 (11.187) years. The evaluation of clinical symptoms and global impression, as well as verbal memory, visual memory, working memory, psychomotor speed, verbal fluency, and executive functioning, was conducted before and after the completion of ECT treatment. RESULTS: We ran a series of paired-samples t tests, and the Bonferroni adjustment for multiple comparisons reduced the significance level to P = 0.004. The neurocognitive domains that demonstrated statistically significant improvement were immediate and delayed verbal memory, and executive functioning, whereas statistical trend was observed for visual memory and psychomotor speed. None of the neurocognitive functions exhibited significant deterioration after the ECT treatment. Electroconvulsive therapy was effective in reducing general symptoms of schizophrenia, resulting in more than 30% decrease in the overall symptom severity measured by the Positive and Negative Syndrome Scale. CONCLUSIONS: Notwithstanding some limitations of this study, the combination of ECT and antipsychotics has improved several neurocognitive domains, without evidence of worsening of any cognitive functions.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Zagreb

Profili:

Avatar Url Nataša Klepac (autor)

Avatar Url Marina Šagud (autor)

Avatar Url Bjanka Vuksan-Ćusa (autor)

Citiraj ovu publikaciju

Vuksan Ćusa, Bjanka; Klepac, Nataša; Jakšić, Nenad, Bradaš, Zoran; Božičević, Marija; Palac, Nataša; Šagud, Marina
The Effects of Electroconvulsive Therapy Augmentation of Antipsychotic Treatment on Cognitive Functions in Patients With Treatment-Resistant Schizophrenia // Journal of ect, [Epub ahead of print] (2017), [Epub ahead of print; 29053485, 5 doi:10.1097/YCT.0000000000000463 (međunarodna recenzija, članak, znanstveni)
Vuksan Ćusa, B., Klepac, N., Jakšić, Nenad, Bradaš, Zoran, Božičević, M., Palac, N. & Šagud, M. (2017) The Effects of Electroconvulsive Therapy Augmentation of Antipsychotic Treatment on Cognitive Functions in Patients With Treatment-Resistant Schizophrenia. Journal of ect, [Epub ahead of print] ([Epub ahead of print), 29053485, 5 doi:10.1097/YCT.0000000000000463.
@article{article, year = {2017}, pages = {5}, DOI = {10.1097/YCT.0000000000000463}, chapter = {29053485}, keywords = {schizophrenia, cognitive functions, electroconvulsive therapy, ECT, memory}, journal = {Journal of ect}, doi = {10.1097/YCT.0000000000000463}, volume = {[Epub ahead of print]}, number = {[Epub ahead of print}, issn = {1095-0680}, title = {The Effects of Electroconvulsive Therapy Augmentation of Antipsychotic Treatment on Cognitive Functions in Patients With Treatment-Resistant Schizophrenia}, keyword = {schizophrenia, cognitive functions, electroconvulsive therapy, ECT, memory}, chapternumber = {29053485} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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