engleski

Leptin/Adiponectin ratio in overweight patients – gender differences

Obesity related atherosclerosis is a systemic disease with a background connected to multiple metabolic-neurohumoral pathways. The leptin/adiponectin ratio (L/A ratio) has been suggested as an atherosclerotic marker in obese patients. The aim of the study was to assess: a) the significance of the L/A ratio in overweight subjects ; b) the relation with anthropometric/metabolic parameters ; c) gender difference. The study included 80 adult male and female, overweight, non-diabetic patients. Biochemical blood analysis, anthropometric and cardiovascular measurements were performed. Serum leptin levels were measured with a RIA test and total adiponectin levels with ELISA. L/A ratios were calculated as ratios between total serum concentrations of leptin and adiponectin. Differences between leptin, adiponectin serum levels and L/A ratios are presented in overweight persons, where females have a significantly higher L/A ratio than men (p<0.001). In men, the L/A ratio showed a positive correlation with total cholesterol levels (p=0.011), LDL (p=0.013) and triglycerides (p=0.032). In females, the L/A ratio correlated with anthropometric parameters of visceral obesity: waist circumference (p=0.001) and waist-to-hip ratio (p=0.025). The L/A ratio could represent an atherosclerotic risk marker of the early stage of obesity. Gender plays a significant role in pathophysiological changes, with different clinical manifestations, where sex hormones have a crucial effect on neurohumoral adipose tissue activity.

adiponectin ; gender ; leptin ; leptin/adiponectin ratio ; overweight

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