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Influence of Body Mass Index on High Sensitive C-Reactive Protein and Procalcitonin Serum Level in the Third Trimester of Pregnancy

Abstract: Objective: It is well accepted that adiposity in general is associated with significantly higher circulatory levels of different inflammatory markers. The aim of this study was to investigate whether such correlation between proinflammatory markers and body mass index (BMI) is present in pregnant women as well. Methods: 30 pregnant women in third trimester of pregnancy were included in the present study. They were categorized based on BMI in three groups: 6 patients with BMI <24.9kg/m2 (BMI I), 11 patients with BMI 25- 29.9 kg/m2 (BMI II) and 13 patients with BMI>30 kg/m2 (BMI III). The inflammatory markers (high sensitive C reactive protein (hsCRP) and procalcitonin (PCT)) were measured between 28 1/7 and 32 0/7 weeks of gestation. Perinatal outcome was analysed in all participants. Results: There was no difference in age and smoking habits between all three grops of subjects. Authors found statistically significant difference in hsCRP mean values between groups: BMI I 4.637 mg/l, BMI II 5.720 mg/l ; BMI III 10.910 mg/l (P= 0.002). However, there was no statistically significant in PCT mean values between groups: BMI I 0.0218 ng/ml ; BMI II 0.0229 ng/ml ; BMI III 0.0261 ng/ml (P= 0.456). Regarding perinatal outcome, there was no difference in gestational age at the time of delivery and incidence of IUGR between these three groups. Cesarian section rate tended to increase with higher BMI in pregnant women. Conclusions: Maternal obesity in third trimester of pregnancy is associated with an increase of hsCRP with increasing BMI category. Further research is needed to determine connection between obesity-induced inflammation and maternal and fetal health.

body mass index, high sensitive c-reactive protein, procalcitonin, pregnancy

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