engleski

Long-term predictors of anxiety and depression in adult patients with asthma

Background It is well established that arxiety and depression are associated with asthma, but there is limited evidence about the persistence of anxiety/depression in asthma. The aim of our study was to assess the longterm predictors of anxiety and depression in adult asthmatic patients. Methods A total of 90 adult asthma patients (63 women, age 18-50 years) with different levels of disease control (28 uncontrolled and 34 partially controlled) were assessed at baseline and at follow-up after 7 years for anxiety, depression and asthma control. The same work-up on both occasions included: demographics, living conditions, medical history (e.g. comorbidities, adherence and exacerbations), Hospital Anxiety and Depression Scale (HADS), Asthma Quality of Life Questionnaire (AQLQ), disease control and lung function. Persistence was defined as the HADS scores The Gentral European Journal of Medicine for anxietv and depression present at baseline and follow-up. Results The FIADS results at follow-up visit showed 36 (40%) asthma patients with affiietv and L3 (L4To) with depression, with the persistence of arxiety in 17(19%) and of depression in 7 (B7o) pslients. Significant predictors of anxiety at follow-up were HADS and AQLQ results at baseline and several parameters of asthma control at follow-up (area under the curve AUC 0.917, 95% confidence interval CI 0.829- 0.969, p< 0.001) and for depressionAQLQ mood disorder domain, asthma control and lung function (AUC 0.947, 95To CI0.870-0.986, p < 0.001).Conclusion Anxiety and depression persist over years in some patients with asthma. The association between mood disorders and asthma suggests potential mutual treatability.

Asthma . Mood disorders . Disease control . Health related quality of life . Long term effects

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