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Potential cancer predictive biomarkers: a case of papillary thyroid cancer


Gerić, Marko; Janušić, Renato; Šarčević, Božena; Garaj-Vrhovac, Vera
Potential cancer predictive biomarkers: a case of papillary thyroid cancer // Biomedical Research and Therapy
Ho Chi Minh City, Vijetnam, 2017. str. 109-109 doi:10.15419/bmrat.v4iS.310 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Potential cancer predictive biomarkers: a case of papillary thyroid cancer

Autori
Gerić, Marko ; Janušić, Renato ; Šarčević, Božena ; Garaj-Vrhovac, Vera

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Biomedical Research and Therapy / - , 2017, 109-109

Skup
The 3rd International Conference Innovations in Cancer Research and Regenerative Medicine

Mjesto i datum
Ho Chi Minh City, Vijetnam, 10-13.09. 2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Papillary thyroid cancer ; Micronucleus test ; Comet assay ; Braf ; Ret
(Papillary thyroid cancer ; micronucleus test ; comet assay ; Braf ; Ret)

Sažetak
Thyroid cancer represents 2.1% of new cancer cases, yet it is the most common endocrine cancer and one of the fastest growing cancer types in the world. The incidence of thyroid cancer is the highest in elderly population (60-69 years), but novel data suggest decline in age when this cancer is frequently diagnosed to 50-59 years. Thyroid cancer is 2-4-fold more common in female population what is usually associated with female hormones and the differences in oxidative stress levels. Since the WHO suggest that roughly 30% of cancer can be prevented, the aim of this study was to evaluate the role of micronucleus test and comet assay as cancer predictive biomarkers. In this study, 36 patients with papillary thyroid cancer (PTC) were recruited in accordance with all ethical standards. The average age of the group was 52±14 years, 28:8 female:male ratio, and 33% of active smokers. Control group was matched for age, gender, and smoking habits (52±14 years, 28:8 female:male ratio, and 33% of active smokers). The number of micronucleated (MNed) cells in human peripheral blood lymphocytes was significantly higher (p<0.05) in PTC group (12.94±5.81) compared to control group (4.36±2.58). Additionally, the comet assay tail moment (TM) was also significantly (p<0.05) higher in the PTC group compared to control group (0.39±0.71 vs 0.14±0.05). These results indicate that people with PTC had more genome damage compared to healthy controls. The immunohistochemical analysis of thyroid revealed 97.2% BRAF positive and 20.6% RET/PTC positive samples. Taken together, the PTC group had more DNA damage what is associated with high prevalence of BRAF mutations and RET/PTC translocations as a consequences of disrupted genome integrity. The results imply that cytogenetic tools might be used in human biomonitoring for identification of high-risk groups but further research is needed to assess normal and cut-off values.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Klinika za tumore

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Emerging Sources Citation Index (ESCI)


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