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Pregled bibliografske jedinice broj: 905217

Cloninger's temperament and character dimensions and dopaminergic genes: DAT1 VNTR and COMT Val158Met polymorphisms


Glavina Jelaš, Ivana; Dević, Ivan; Karlović, Dalibor
Cloninger's temperament and character dimensions and dopaminergic genes: DAT1 VNTR and COMT Val158Met polymorphisms // Psychiatria Danubina, 30 (2018), 1; 41-50 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 905217 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cloninger's temperament and character dimensions and dopaminergic genes: DAT1 VNTR and COMT Val158Met polymorphisms

Autori
Glavina Jelaš, Ivana ; Dević, Ivan ; Karlović, Dalibor

Izvornik
Psychiatria Danubina (0353-5053) 30 (2018), 1; 41-50

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Personality, DAT1 VNTR, COMT Val158Met, Cloninger, Dopaminergic genes

Sažetak
Background: the objective of this study was to examine the associations between Cloninger temperament and character dimensions with the DAT1 VNTR and COMT Val158Met polymorphisms. Subjects and Methods: The study was conducted on 101 subjects, consisting of students of the Police College in Zagreb and staff of the Sestre Milosrdnice University Hospital in Zagreb. The Cloninger Temperament and Character Inventory (TCI) was used to test personality traits. Results: A main effect of the DAT1 VNTR polymorphism was found on the subscale self-directedness – SD2 (F=5, 18, df=1, p<0.05), where a higher result was detected in carriers of the 9/9 genotype (M=7.33, SD=0.51) than those carrying the 10-repeat allele (M=6.02, SD=1.36). Also for the COMT Val158Met polymorphism, main effects were found on the subscales: NS3 (novelty seeking) (F=5.18, df=1, p<0.05), where a higher result was found in carriers of the Val allele (M=5.03, SD=2.22) than in carriers of the Met/Met genotype (MD=4.76, SD=2.37), SD3 (self-directedness) (F=5.18, df=1, p<0.05) where a higher result was found in carriers of the Val/Val genotype (M=4.50, SD=0.78) than in those carrying the Met allele (M=3.80, SD=1.31) ; C3 (cooperativeness) (F=5.18, df=1, p<0.05), where a high result was found in carriers of the Val allele (M=5.68, SD=1.25) than those carrying the Met/Met genotype (M=5.08, SD=1.11) ; and ST3 (self-transcendence) (F=5.18, df=1, p<0.05), where a higher result was found in carriers of the Met/Met genotype (M=3.46, SD=2.37) than carriers of the Val allele (M=2.69, SD=1.84). Two significant interactions were detected, on the subscale NS3 (novelty seeking) (F=5.18, df=1, p<0.05), and on the subscale C2 (cooperativeness) (F=5.18, df=1, p<0.05). Conclusions Cloninger's (1987) hypothesis about negative relationship between novelty seeking and dopamine was confirmed on allele level, because higher novelty seeking was found in Val allele carriers comparing to Met/Met genotype carriers.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Psihologija



POVEZANOST RADA


Projekt / tema
134-0000000-3372 - Molekularno-biokemijski čimbenici u bolesnika s depresivnim poremećajem (Dalibor Karlović, )

Ustanove
KBC "Sestre Milosrdnice",
Institut društvenih znanosti Ivo Pilar, Zagreb,
MUP Policijska akademija – Visoka policijska škola, Zagreb

Profili:

Avatar Url Ivan Dević (autor)

Avatar Url Dalibor Karlović (autor)

Avatar Url Ivana Glavina Jelaš (autor)

Citiraj ovu publikaciju

Glavina Jelaš, Ivana; Dević, Ivan; Karlović, Dalibor
Cloninger's temperament and character dimensions and dopaminergic genes: DAT1 VNTR and COMT Val158Met polymorphisms // Psychiatria Danubina, 30 (2018), 1; 41-50 (međunarodna recenzija, članak, znanstveni)
Glavina Jelaš, I., Dević, I. & Karlović, D. (2018) Cloninger's temperament and character dimensions and dopaminergic genes: DAT1 VNTR and COMT Val158Met polymorphisms. Psychiatria Danubina, 30 (1), 41-50.
@article{article, year = {2018}, pages = {41-50}, keywords = {Personality, DAT1 VNTR, COMT Val158Met, Cloninger, Dopaminergic genes}, journal = {Psychiatria Danubina}, volume = {30}, number = {1}, issn = {0353-5053}, title = {Cloninger's temperament and character dimensions and dopaminergic genes: DAT1 VNTR and COMT Val158Met polymorphisms}, keyword = {Personality, DAT1 VNTR, COMT Val158Met, Cloninger, Dopaminergic genes} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE