Beta-lactam rearrangements into five-membered heterocycles (CROSBI ID 244252)
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Podaci o odgovornosti
Dražić, Tonko ; Roje, Marin
engleski
Beta-lactam rearrangements into five-membered heterocycles
β-Lactams are compounds of great importance in both medicinal chemistry and as building blocks for the synthesis of different types of biologically relevant compounds. Among other transformations, β-lactams can easily be rearranged into five-membered heterocycles. The rearrangement occurs by cleavage of any of four β-lactam bonds. The type of final five-membered ring mainly depends on the side chain groups of starting β-lactam, as well as reaction conditions. Furthermore, rearrangement reactions are often stereoselective, with product rings retaining the stereochemistry of β-lactams. The ability of β-lactams to form a variety of diversely decorated five-membered heterocycles, often in stereoselective fashion, makes this class of compounds attractive synthons in organic chemistry. This review covers the progress in the field within last ten years.
hydantoin ; imidazolidinone ; imidazolidinethione ; imidazolone ; β-lactam ; pyrrolidinone ; thiohydantoin ; transformation
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Podaci o izdanju
53 (9)
2017.
953-962
objavljeno
0009-3122
1573-8353
10.1007/s10593-017-2156-z