Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 904168

Negative environmental impacts of antibiotic- contaminated effluents from pharmaceutical industries


Bielen, Ana; Šimatović, Ana; Kosić-Vukšić, Josipa; Senta, Ivan; Ahel, Marijan; Babić, Sanja; Jurina, Tamara; González Plaza, Juan José; Milaković, Milena; Udiković-Kolić, Nikolina
Negative environmental impacts of antibiotic- contaminated effluents from pharmaceutical industries // Water research, 126 (2017), 79-87 doi:10.1016/j.watres.2017.09.019 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 904168 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Negative environmental impacts of antibiotic- contaminated effluents from pharmaceutical industries

Autori
Bielen, Ana ; Šimatović, Ana ; Kosić-Vukšić, Josipa ; Senta, Ivan ; Ahel, Marijan ; Babić, Sanja ; Jurina, Tamara ; González Plaza, Juan José ; Milaković, Milena ; Udiković-Kolić, Nikolina

Izvornik
Water research (0043-1354) 126 (2017); 79-87

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antibiotic pollution Drug manufacturing, Macrolides, Antibiotic resistance, Ecotoxicity

Sažetak
Effluents from pharmaceutical industries are recognized as significant contributors to aquatic pollution with antibiotics. Although such pollution has been mostly reported in Asia, knowledge on industrial discharges in other regions of the world, including Europe, and on the effects associated with such exposures is still limited. Thus, we performed chemical, microbiological and ecotoxicological analyses of effluents from two Croatian pharmaceutical industries during four seasons. In treated effluents of the company synthesizing macrolide antibiotic azithromycin (AZI), the total concentration of AZI and two macrolide by-products from its synthesis was 1e3 orders of magnitude higher in winter and springtime (up to 10.5 mg/L) than during the other two seasons (up to 638 mg/L). Accordingly, the highest total concentrations (up to 30 mg/L) in the recipient river were measured in winter and spring. Effluents from second company formulating veterinary antibiotics contained fluoroquinolones, trimethoprim, sulfonamides and tetracyclines ranging from low mg/L to approx. 200 mg/L. Low concentrations of these antibiotics, from below the limit of quantification to approx. few mg/L, have also been measured in the recipient stream. High frequency of culturable bacteria resistant to AZI (up to 83%) or sulfamethazine (up to 90%) and oxytetracycline (up to 50%) were also found in studied effluents. Finally, we demonstrated that toxicity to algae and water fleas often exceeded the permitted values. Most highly contaminated effluents induced multiple abnormalities in zebrafish embryos. In conclusion, using a wide array of analyses we have demonstrated that discharges from pharmaceutical industries can pose a significant ecological and public health concern due to their toxicity to aquatic organisms and risks for promoting development and spread of antibiotic resistance.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Biotehnologija



POVEZANOST RADA


Projekti:
HRZZ-UIP-2014-09-9350 - Istraživanje utjecaja otpadnih voda iz farmaceutskih industrija na sastav i profil antibiotičke rezistencije izloženih mirkobnih zajednica u slatkovodnim sedimentima (WINAR) (Udiković Kolić, Nikolina, HRZZ - 2014-09) ( POIROT)

Ustanove:
Prehrambeno-biotehnološki fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Nastavni zavod za javno zdravstvo "Dr. Andrija Štampar"

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Bielen, Ana; Šimatović, Ana; Kosić-Vukšić, Josipa; Senta, Ivan; Ahel, Marijan; Babić, Sanja; Jurina, Tamara; González Plaza, Juan José; Milaković, Milena; Udiković-Kolić, Nikolina
Negative environmental impacts of antibiotic- contaminated effluents from pharmaceutical industries // Water research, 126 (2017), 79-87 doi:10.1016/j.watres.2017.09.019 (međunarodna recenzija, članak, znanstveni)
Bielen, A., Šimatović, A., Kosić-Vukšić, J., Senta, I., Ahel, M., Babić, S., Jurina, T., González Plaza, J., Milaković, M. & Udiković-Kolić, N. (2017) Negative environmental impacts of antibiotic- contaminated effluents from pharmaceutical industries. Water research, 126, 79-87 doi:10.1016/j.watres.2017.09.019.
@article{article, author = {Bielen, Ana and \v{S}imatovi\'{c}, Ana and Kosi\'{c}-Vuk\v{s}i\'{c}, Josipa and Senta, Ivan and Ahel, Marijan and Babi\'{c}, Sanja and Jurina, Tamara and Gonz\'{a}lez Plaza, Juan Jos\'{e} and Milakovi\'{c}, Milena and Udikovi\'{c}-Koli\'{c}, Nikolina}, year = {2017}, pages = {79-87}, DOI = {10.1016/j.watres.2017.09.019}, keywords = {Antibiotic pollution Drug manufacturing, Macrolides, Antibiotic resistance, Ecotoxicity}, journal = {Water research}, doi = {10.1016/j.watres.2017.09.019}, volume = {126}, issn = {0043-1354}, title = {Negative environmental impacts of antibiotic- contaminated effluents from pharmaceutical industries}, keyword = {Antibiotic pollution Drug manufacturing, Macrolides, Antibiotic resistance, Ecotoxicity} }
@article{article, author = {Bielen, Ana and \v{S}imatovi\'{c}, Ana and Kosi\'{c}-Vuk\v{s}i\'{c}, Josipa and Senta, Ivan and Ahel, Marijan and Babi\'{c}, Sanja and Jurina, Tamara and Gonz\'{a}lez Plaza, Juan Jos\'{e} and Milakovi\'{c}, Milena and Udikovi\'{c}-Koli\'{c}, Nikolina}, year = {2017}, pages = {79-87}, DOI = {10.1016/j.watres.2017.09.019}, keywords = {Antibiotic pollution Drug manufacturing, Macrolides, Antibiotic resistance, Ecotoxicity}, journal = {Water research}, doi = {10.1016/j.watres.2017.09.019}, volume = {126}, issn = {0043-1354}, title = {Negative environmental impacts of antibiotic- contaminated effluents from pharmaceutical industries}, keyword = {Antibiotic pollution Drug manufacturing, Macrolides, Antibiotic resistance, Ecotoxicity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index


Citati:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font