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Pregled bibliografske jedinice broj: 904157

Hippocampal Filopodia but not Growth Cones can Climb Over 600 nm Steps


Lien, Linh Thuy; Ban, Jelena; Tormen, Massimo; Migliorini, Elisa; Grenci, Gianluca; Pozzato, Alessandro; Torre, Vincent
Hippocampal Filopodia but not Growth Cones can Climb Over 600 nm Steps // Biophysical Journal
Philadelphia, USA, 2013. 829-PosB598, 1 doi:10.1016/j.bpj.2012.11.914 (poster, međunarodna recenzija, sažetak, znanstveni)


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Naslov
Hippocampal Filopodia but not Growth Cones can Climb Over 600 nm Steps

Autori
Lien, Linh Thuy ; Ban, Jelena ; Tormen, Massimo ; Migliorini, Elisa ; Grenci, Gianluca ; Pozzato, Alessandro ; Torre, Vincent

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Biophysical Journal / - , 2013

Skup
Biophysical Society, 57th Annual Meeting

Mjesto i datum
Philadelphia, USA, 2-6.2.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
guidance molecules ; growth cone

Sažetak
Guidance molecules, such as Sema3A or Netrin-1, can induce growth cone repulsion or attraction in the presence of a flat surface, but very little is known of the action of guidance molecules in the presence of obstacles. In order to address this issue, we analysed the action of Netrin-1 molecules in the presence of patterned polydimethylsiloxane (PDMS) surfaces with lines with a height varying from 100 to 600 nm. Filopodia can crawl over these lines easily, but not neurites. Indeed axons and thick dendrites are able to cross lines with a height of 100 nm, but progressively less when the line height is increased. When neurons are grown for 3 days over patterned surfaces it was possible to label selectively axons with axonal neurofilament marker SMI 312 and dendrites with microtubule associated protein 2 (MAP2): axons and dendrites do not differ in their ability to cross lines with a height varying from 100 to 600 nm. When axons and dendrites grow along lines, a clear staining for the adhesion marker paxillin was observed, but not when neurites cross the lines.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Interdisciplinarne biotehničke znanosti



POVEZANOST RADA


Profili:

Avatar Url Jelena Ban (autor)

Poveznice na cjeloviti tekst rada:

doi www.cell.com

Citiraj ovu publikaciju:

Lien, Linh Thuy; Ban, Jelena; Tormen, Massimo; Migliorini, Elisa; Grenci, Gianluca; Pozzato, Alessandro; Torre, Vincent
Hippocampal Filopodia but not Growth Cones can Climb Over 600 nm Steps // Biophysical Journal
Philadelphia, USA, 2013. 829-PosB598, 1 doi:10.1016/j.bpj.2012.11.914 (poster, međunarodna recenzija, sažetak, znanstveni)
Lien, L., Ban, J., Tormen, M., Migliorini, E., Grenci, G., Pozzato, A. & Torre, V. (2013) Hippocampal Filopodia but not Growth Cones can Climb Over 600 nm Steps. U: Biophysical Journal doi:10.1016/j.bpj.2012.11.914.
@article{article, year = {2013}, pages = {1}, DOI = {10.1016/j.bpj.2012.11.914}, chapter = {829-PosB598}, keywords = {guidance molecules, growth cone}, doi = {10.1016/j.bpj.2012.11.914}, title = {Hippocampal Filopodia but not Growth Cones can Climb Over 600 nm Steps}, keyword = {guidance molecules, growth cone}, publisherplace = {Philadelphia, USA}, chapternumber = {829-PosB598} }
@article{article, year = {2013}, pages = {1}, DOI = {10.1016/j.bpj.2012.11.914}, chapter = {829-PosB598}, keywords = {guidance molecules, growth cone}, doi = {10.1016/j.bpj.2012.11.914}, title = {Hippocampal Filopodia but not Growth Cones can Climb Over 600 nm Steps}, keyword = {guidance molecules, growth cone}, publisherplace = {Philadelphia, USA}, chapternumber = {829-PosB598} }

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