hrvatski

Značenje reakcija biotransformacija u pojavi idiosinkratskih reakcija lijekova

Idiosyncratic drug reactions (IDRs) are rare, dose independent adverse drug reactions. Although non-predictable they are not idiopathic and their causes can be rationalized. Drugs susceptible to IDRs usually undergo extensive metabolism. Most common cause of IDRs are reactive metabolites generated through drug biotransformation. In this paper an overview of drugs susceptible to IDRs is given, based on eff ected organs. IDRs on skin are illustrated with metabolism phenytoin and nevirapine. Hematological IDRs are exemplifi ed with clozapine and felbamate. Hepatotoxicity related to IDRs is explained on valproic acid, troglitazone and ximelagatran. Among strategies on how to reduce occurrence of IDRs include avoidance of specifi c functional groups (toxicophores) present a viable option.

Idiosinkratske reakcije, metabolizam

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