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Pregled bibliografske jedinice broj: 899492

Comparison of the Effects of Low Intra- Abdominal Pressure and Pentoxifylline on Oxidative Stress during CO2 Pneumoperitoneum in Rabbits


Nesek Adam, Višnja; Vnuk, Dražen; Rašić, Žarko; Rumenjak, Vlatko; Kos, Josip; Krstonijević, Zoran
Comparison of the Effects of Low Intra- Abdominal Pressure and Pentoxifylline on Oxidative Stress during CO2 Pneumoperitoneum in Rabbits // European surgical research, 43 (2009), 4; 330-337 doi:10.1159/000237747 (međunarodna recenzija, članak, znanstveni)


Naslov
Comparison of the Effects of Low Intra- Abdominal Pressure and Pentoxifylline on Oxidative Stress during CO2 Pneumoperitoneum in Rabbits

Autori
Nesek Adam, Višnja ; Vnuk, Dražen ; Rašić, Žarko ; Rumenjak, Vlatko ; Kos, Josip ; Krstonijević, Zoran

Izvornik
European surgical research (0014-312X) 43 (2009), 4; 330-337

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CO2 pneumoperitoneum, ishemijsko/reperfuzijska ozljeda , oxidacijski stres , pentoksifilin
(CO2 pneumoperitoneum, ischemia/reperfusion injury, oxidative stress, pentoxifylline)

Sažetak
The aim of this study was to investigate the effect of low-pressure pneumoperitoneum and pentoxifylline, a methylxanthine derivative, in the prevention of injury caused by free oxygen radicals generated during CO(2 )pneumoperitoneum. Twenty-eight rabbits were allocated randomly to 4 groups. Control group rabbits (group 1) were subjected to anesthesia for 60 min ; group 2 and 3 animals were subjected to a CO(2) pneumoperitoneum (15 or 7 mm Hg) ; and group 4 rabbits received 50 mg/kg pentoxifylline, followed by a 15-mm-Hg pneumoperitoneum. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), lipid hydroperoxide, glutathione reductase and total antioxidant status were measured. Compared with group 1, a significant increase in lipid hydroperoxide levels at the end of the pneumoperitoneum and 30 min after deflation and a significant decrease in total antioxidant status 24 h after deflation were recorded in group 2. In addition, a significant increase was observed in ALT, AST and LDH levels. These changes were attenuated by low- pressure pneumoperitoneum, whereas pentoxifylline pretreatment appeared to attenuate only transaminase levels. Low- pressure pneumoperitoneum could attenuate ischemia/reperfusion injury induced by CO(2 )pneumoperitoneum in a rabbit model whereas pentoxifylline pretreatment appeared to attenuate only transaminase levels. Pentoxifylline did not prevent the development of oxidative stress.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Veterinarski fakultet, Zagreb,
Klinička bolnica "Sveti Duh",
Sveučilište Libertas

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE


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