engleski

Herbal products as potential therapy for functional dyspepsia

Functional dyspepsia (FD) is defined as the presence of postprandial fullness, early satiation, epigastric burning, or pain in the absence of other systemic, metabolic, or organic disease. FD is divided into the postprandial distress syndrome (PDS) and the epigastric pain syndrome (EPS), with significant overlap with gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) symptoms. Current recommended therapy is antisecretory drugs (PPIs or H2RAs), but the recurrence of symptoms often occurs after an intermission in therapy. Prokintetic drugs, such as metoclopramide and domperidone, are especially effective for PDS, but like with antisecretory drugs, long term therapy is not recommended. Acotiamide could be as effective as prokinetics. Antidepressants (SSR1) have shown some results, as well as bismuth salts and simethicone, but adequate trials are needed. Various numbers of Chinese, Korean, and Iranian herbs are excluded from this research. Alginates provide effects for GERD, but FD effects are doubtful. Data shows that the SWT5 is as effective as pro kinetics, especially with IBS overlap. Peppermint and caraway oil, star anise, ginger, and artichoke leaf extract have better efficacy than placebo in the treatment of functional dyspepsia. Olive oil, red pepper, curcuma, dandelion, and Melissa could be useful, but well developed prospective clinical trials are needed.

functional dyspepsia, herbal products, potential therapy

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