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Pregled bibliografske jedinice broj: 898743

Changes in total plasma and serum N-glycome composition and patient-controlled analgesia after major abdominal surgery


Gudelj, Ivan; Baciarello, Marco; Ugrina, Ivo; De Gregori, Manuela; Napolioni, Valerio, Ingelmo, Palmo M.; Bugada, Dario; De Gregori, Simona; Đerek, Lovorka; Pučić-Baković, Maja; Novokmet, Mislav et al.
Changes in total plasma and serum N-glycome composition and patient-controlled analgesia after major abdominal surgery // Scientific Reports, 6 (2016) doi:10.1038/srep31234 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 898743 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Changes in total plasma and serum N-glycome composition and patient-controlled analgesia after major abdominal surgery

Autori
Gudelj, Ivan ; Baciarello, Marco ; Ugrina, Ivo ; De Gregori, Manuela ; Napolioni, Valerio, Ingelmo, Palmo M. ; Bugada, Dario ; De Gregori, Simona ; Đerek, Lovorka ; Pučić-Baković, Maja ; Novokmet, Mislav ; Gornik, Olga ; Saccani Jotti, Gloria ; Meschi, Tiziana ; Lauc, Gordan ; Allegri, Massimo

Izvornik
Scientific Reports (2045-2322) 6 (2016); 31234, 0

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
N-glycome ; plasma ; serum ; abdominal surgery

Sažetak
Systemic inflammation participates to the complex healing process occurring after major surgery, thus directly affecting the surgical outcome and patient recovery. Total plasma N- glycome might be an indicator of inflammation after major surgery, as well as an anti- inflammatory therapy response marker, since protein glycosylation plays an essential role in the inflammatory cascade. Therefore, we assessed the effects of surgery on the total plasma N-glycome and the association with self- administration of postoperative morphine in two cohorts of patients that underwent major abdominal surgery. We found that plasma N- glycome undergoes significant changes one day after surgery and intensifies one day later, thus indicating a systemic physiological response. In particular, we observed the increase of bisialylated biantennary glycan, A2G2S[3, 6]2, 12 hours after surgery, which progressively increased until 48 postoperative hours. Most changes occurred 24 hours after surgery with the decrease of most core- fucosylated biantennary structures, as well as the increase in sialylated tetraantennary and FA3G3S[3, 3, 3]3 structures. Moreover, we observed a progressive increase of sialylated triantennary and tetraantennary structures two days after surgery, with a concomitant decrease of the structures containing bisecting N- acetylglucosamine along with bi- and trisialylated triantennary glycans. We did not find any statistically significant association between morphine consumption and plasma N- glycome.

Izvorni jezik
Engleski



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinička bolnica "Merkur",
GENOS d.o.o.

Citiraj ovu publikaciju

Gudelj, Ivan; Baciarello, Marco; Ugrina, Ivo; De Gregori, Manuela; Napolioni, Valerio, Ingelmo, Palmo M.; Bugada, Dario; De Gregori, Simona; Đerek, Lovorka; Pučić-Baković, Maja; Novokmet, Mislav et al.
Changes in total plasma and serum N-glycome composition and patient-controlled analgesia after major abdominal surgery // Scientific Reports, 6 (2016) doi:10.1038/srep31234 (međunarodna recenzija, članak, znanstveni)
Gudelj, I., Baciarello, M., Ugrina, I., De Gregori, M., Napolioni, Valerio, Ingelmo, Palmo M., Bugada, D., De Gregori, S., Đerek, L., Pučić-Baković, M. & Novokmet, M. (2016) Changes in total plasma and serum N-glycome composition and patient-controlled analgesia after major abdominal surgery. Scientific Reports, 6 doi:10.1038/srep31234.
@article{article, year = {2016}, DOI = {10.1038/srep31234}, chapter = {31234}, keywords = {N-glycome, plasma, serum, abdominal surgery}, journal = {Scientific Reports}, doi = {10.1038/srep31234}, volume = {6}, issn = {2045-2322}, title = {Changes in total plasma and serum N-glycome composition and patient-controlled analgesia after major abdominal surgery}, keyword = {N-glycome, plasma, serum, abdominal surgery}, chapternumber = {31234} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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