engleski

PROCALCITONIN AND HIGH SENSITIVE C-REACTIVE PROTEIN IN PREECLAMPSIA

BACKGROUND-AIM Preeclampsia (PE) is a heterogeneous syndrome, ranging from mild hypertension and proteinuria to severe preeclampsia with complications. This severe pregnancy complication may be associated with an enhanced maternal inflammatory response and endothelial cell activation. The aim of study was to evaluate levels of procalcitonin (PCT) and high sensitive C-reactive protein (hsCRP) in women in third trimester of pregnancy with preeclampsia compared with healthy pregnant women. METHODS Blood samples were collected from 12 women with preeclampsia, divided in two groups by severity of PE and term of delivery (6 mild preeclampsia with term delivery, 6 severe preeclampsia and preterm delivery) and 23 healthy pregnant women at third trimester. Diagnostic criteria for PE were based on international guidelines and defined as hypertension (systolic blood pressure ≥ 140 mm Hg and diastolic blood pressure ≥ 90 mmHg after 20 weeks gestation) and proteinuria with excretion of 300 mg of protein in 24-hour urin. Levels of PCT were determined by the electrochemilunescence immunoassay (ECLIA, Cobas e 601 analyzers, Roche Diagnostics Ltd. Mannheim, Germany) and hsCRP by the particle enhanced turbidimetric immunoassay (PETIA, Dimension EXL analyzers, Siemens Healthcare GmbH, Germany). RESULTS There was no statistically significant difference in serum PCT (median levels for both group were 0.02 ng/ml, P = 0.115) and hsCRP levels between healthy pregnant women (median level was 5.59 mg/L) and women who developed preeclampsia (median level was 7.73 mg/L) (P = 0.442). There was no statistically significant difference in serum PCT (P = 0.720) and hsCRP (P = 0.334) levels between women with mild preeclampsia and term delivery (median levels were for PCT = 0.02 ng/ml and hsCRP = 8.85 mg/L) and women with severe preeclampsia and preterm delivery (median levels were for PCT = 0.02 ng/ml and hsCRP = 5.61 mg/L). CONCLUSIONS In this preliminary study, there was no difference in serum PCT and hsCRP levels between healthy pregnancies and women who developed preeclampsia. Since this research is a part of larger, still ongoing study, the final results may be different.

Procalcitonin, hsCRP, preeclampsia

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