engleski

Novel method of drug delivery system

Design and construction of a complete drug delivery system, from a drug nano-carrier to an efficient system for drug activation in a localized volume of the human body requires a multidisciplinary approach and substantial investment. Porous materials possess a large surface area and thus have the capability to store different molecules (drugs) within their structure making them potential drug carriers. As an ideal canditate porous Fe3O4 structures can be used as a vehicle for the transport of drugs adsorbed onto their surface. This material enables controlled release of the chemical payload via activation by a magnetic field. Porous structures made up of Fe3O4 nanoparticles were used to adsorb methyl blue in water. Controlled release of the methyl blue to water was then achieved by application of a magnetic field. Application of a pure DC field did not result in any release. Application of a pure AC field caused released of the methyl blue. However, a combination of both DC and AC fields resulted in much faster release. The mechanism by which this operated is believed to result from viscous friction. Nanoparticles are strongly aligned in the DC field and oscillate under the influence of the AC field. This study demonstrates a concept for controlled drug delivery, where pharmaceutical molecules, similar to methyl blue, would be adsorbed onto porous Fe3O4 structure and the released at a target by application of appropriately localised magnetic fields. In an expanded research, we developed superparamagnetic nanoparticles for activation of the MscL (Large Conductance Mechanosensitive Channel) nanovalves by magnetic field. Synthesised CoFe2O4 nanoparticles with the radius less than 10 nm were labelled by -SH groups for attachment to MscL. Activation of MscL by magnetic field with the nanoparticles attached was examined by the patch clamp technique showing that the number of activated channels under ramp pressure increased upon application of the magnetic field. Finally, in this research we present two promising concepts of precise drug delivery system in very early stages.

Drug delivery system, porous Fe3O4, magnetic fields

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