Coumarinyl thiosemicarbazides as antimicrobial agents (CROSBI ID 242738)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Molnar, Maja ; Tomić, Marinko ; Pavić, Valentina
engleski
Coumarinyl thiosemicarbazides as antimicrobial agents
A two series of coumarinyl thiosemicarbazides were synthesized. One series derived from coumarin core substituted in position 7 and another from coumarin core substituted in position 4. All compounds were obtained in reaction of corresponding hydrazide and various isothiocyanates. Structures of all the compounds were confirmed by both 1H and 13C NMR and mass spectrometry. An antimicrobial investigation of compounds was performed on four bacterial strains, Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus where 2-(2-(7-hydroxy-2- oxo-2H- chromen-4-yl)acetyl)-N-(2, 4, 6- trichlorophenyl)hydrazine-1-carbothioamide was found to be the most potent one, against B. subtilis.
thiosemicarbazide ; coumarin ; antibacterial activity
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Podaci o izdanju
51 (12)
2018.
1078-1081
objavljeno
0091-150X
1573-9031
10.1007/s11094-018-1743-3