Biological study on novel coumarinyl 1, 3, 4- oxadiazoles (CROSBI ID 242736)
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Podaci o odgovornosti
Molnar, Maja ; Amić, Ana ; Pavić, Valentina ; Kovač, Tihomir ; Kovač, Marija ; Has-Schön, Elizabeta
engleski
Biological study on novel coumarinyl 1, 3, 4- oxadiazoles
Coumarinyl 1, 3, 4-oxadiazoles were synthesized from Schiff bases and acetic anhydride. All compounds were characterized by melting points and their structures confirmed by mass, 1H and 13C NMR spectrometry. These novel coumarinyl derivatives were subjected to antibacterial, antifungal, antaflatoxigenic and antioxidant activity. Their activity varied depending on their structure, where 2-(3-acetyl-5-(((4- methyl-2-oxo-2H-chromen-7-yl)oxy)methyl)-2, 3- dihydro-1, 3, 4-oxadiazol-2-yl)-1, 4-phenylene diacetate showed a significant antioxidant and antibacterial activity on B. Subtilis. 4-(3- Acetyl-5-(((4-methyl-2-oxo-2H-chromen-7- yl)oxy)methyl)-2, 3-dihydro-1, 3, 4-oxadiazol- 2- yl)-1, 2-phenylene diacetate was found to possess an excellent antifungal and antiaflatoxigenic activity.
coumarin ; 1, 3, 4-oxadiazole ; antibacterial ; antifungal ; antimycotoxigenic activity
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Podaci o izdanju
Povezanost rada
Biotehnologija, Kemija