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Mechanical and in-vitro performance of porous hydroxyapatite/poly(lactic acid)/polycaprolactone composite scaffolds (CROSBI ID 652426)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa

Ivanković, Hrvoje ; Rogina, Anamarija ; Milovac, Dajana ; Gloria, Gallego Ferrer ; Ivanković, Marica Mechanical and in-vitro performance of porous hydroxyapatite/poly(lactic acid)/polycaprolactone composite scaffolds // The international journal of artificial organs / Remuzzi, Andrea ; Stegmayr, Bernd (ur.). 2017. str. 442-x

Podaci o odgovornosti

Ivanković, Hrvoje ; Rogina, Anamarija ; Milovac, Dajana ; Gloria, Gallego Ferrer ; Ivanković, Marica

engleski

Mechanical and in-vitro performance of porous hydroxyapatite/poly(lactic acid)/polycaprolactone composite scaffolds

Hydrothermal transformation of aragonitic cuttlefish bone into hydroxyapatite (HAp) was performed while retaining the cuttlebone architecture. Composite structures were obtained using vacuum impregnation technique with different PCL/PLA ratios. Final three-component systems were characterized by X-ray diffraction, FTIR spectroscopy, TGA and SEM. Influence of different polymer ratio on mechanical properties was investigated by compressive test, while cytotoxicity of materials was evaluated by MTS assay. Results X-ray diffraction, FTIR spectroscopy and SEM confirmed thermal conversion of aragonite to HAp maintaining original cuttlefish bone microstructure. Compressive test showed that the PCL/PLA-coated HAp scaffold resulted in a material with improved mechanical properties with interconnected porous structure indispensable for tissue growth and vascularization. Variation of PCL-PLA ratio has resulted in alteration of scaffolds elasticity. Additionally, prepared PCL/PLA-HAp systems are non-cytotoxic.

Hdroxyapatite, PCL, PLA, mechanical properties, citotoxicity

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Podaci o prilogu

442-x.

2017.

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objavljeno

Podaci o matičnoj publikaciji

The international journal of artificial organs

Remuzzi, Andrea ; Stegmayr, Bernd

Beč: Wichtig Publishing

0391-3988

Podaci o skupu

ESAO-IFAO Congress, 2017

poster

06.09.2017-09.09.2017

Beč, Austrija

Povezanost rada

Temeljne tehničke znanosti

Indeksiranost